TdT (DNTT) Rabbit Monoclonal Antibody [Clone ID: OTIR1E10]

Specifications

Product Data
Clone Name	OTIR1E10
Applications	IHC
Recommend Dilution	IHC 1:2000
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to the N-terminus of human TDT (NP_001017520) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1.00mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
Predicted Protein Size	58.4 kDa
Gene Name	DNA nucleotidylexotransferase
Database Link	NP_004079 Entrez Gene 1791 Human UniProt ID P04053
Background	This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Synonyms	TDT
Reference Data
Protein Pathways	Hematopoietic cell lineage, Non-homologous end-joining

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