BNP (NPPB) Rabbit Monoclonal Capture Antibody [Clone ID: OTIR5G8]

Specifications

Product Data
Clone Name	OTIR5G8
Applications	ELISA, LMNX
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human BNP. The exact sequence is proprietary.
Formulation	PBS (pH7.3) containing 0.05% sodium azide
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C. Avoid repeat freeze/thaw cycles.
Predicted Protein Size	14.7 kDa
Gene Name	natriuretic peptide B
Database Link	NP_002512 Entrez Gene 4879 Human UniProt ID P16860
Background	This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Synonyms	BNP; Iso-ANP
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Stem cell - Pluripotency

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