Thymidylate Synthase (TYMS) Mouse Monoclonal Antibody [Clone ID: OTI10F12]

Specifications

Product Data
Clone Name	OTI10F12
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TYMS (NP_001062) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	35.5 kDa
Gene Name	thymidylate synthetase
Database Link	NP_001062 Entrez Gene 22171 MouseEntrez Gene 29261 RatEntrez Gene 7298 Human UniProt ID P04818
Background	Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
Synonyms	HST422; TMS; TS
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism

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