APPBP1 (NAE1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1E10]

Specifications

Product Data
Clone Name	OTI1E10
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-274 of human NAE1 (NP_001018170) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50.4 kDa
Gene Name	NEDD8 activating enzyme E1 subunit 1
Database Link	NP_001018170 Entrez Gene 84019 RatEntrez Gene 234664 MouseEntrez Gene 8883 Human UniProt ID Q13564
Background	The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms	A-116A10.1; APPBP1; HPP1; ula-1
Reference Data
Protein Pathways	Alzheimer's disease

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