ErbB 4 (ERBB4) Mouse Monoclonal Antibody [Clone ID: OTI1H6]

Specifications

Product Data
Clone Name	OTI1H6
Applications	IHC, WB
Recommend Dilution	IHC 1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 992-1308 of human ERBB4 (NP_005226) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	144.2 kDa
Gene Name	erb-b2 receptor tyrosine kinase 4
Database Link	NP_005226 Entrez Gene 13869 MouseEntrez Gene 59323 RatEntrez Gene 2066 Human UniProt ID Q15303
Background	This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Synonyms	ALS19; HER4; p180erbB4
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Calcium signaling pathway, Endocytosis, ErbB signaling pathway

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