Mesothelin (MSLN) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3E10]

Specifications

Product Data
Clone Name	OTI3E10
Applications	LMNX, WB
Recommend Dilution	WB 1:2000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 270-493 of human MSLN (NP_005814) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	62.7 kDa
Gene Name	mesothelin
Database Link	NP_005814 Entrez Gene 10232 Human UniProt ID Q13421
Background	This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Synonyms	MPF; SMRP
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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