HDAC8 Mouse Monoclonal Antibody [Clone ID: OTI5F7]

Specifications

Product Data
Clone Name	OTI5F7
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-243 of human HDAC8 (NP_060956) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	41.6 kDa
Gene Name	histone deacetylase 8
Database Link	NP_060956 Entrez Gene 70315 MouseEntrez Gene 363481 RatEntrez Gene 55869 Human UniProt ID Q9BY41
Background	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms	CDA07; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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