PTPN22 Mouse Monoclonal Antibody [Clone ID: OTI6B1]

Specifications

Product Data
Clone Name	OTI6B1
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 359-449 of human PTPN22 (NP_057051) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	91.5 kDa
Gene Name	protein tyrosine phosphatase, non-receptor type 22
Database Link	NP_057051 Entrez Gene 26191 Human UniProt ID Q9Y2R2
Background	This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Synonyms	LYP; LYP1; LYP2; PEP; PTPN8
Reference Data
Protein Families	Druggable Genome, Phosphatase

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