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p63 (TP63) Mouse Monoclonal Antibody [Clone ID: OTI12A10]
CAT＃: TA815185S
P40 (ΔNp63) mouse monoclonal antibody,clone OTI12A10
Size: 100 ul
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Specifications
| Product Data | |
| Clone Name | OTI12A10 |
| Applications | IHC |
| Recommend Dilution | IHC 1:1800 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human p40 (NP_001108452). The exact sequence is proprietary. |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1.00mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage Condition | Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws. |
| Predicted Protein Size | 65.6 kDa |
| Gene Name | tumor protein p63 |
| Database Link | |
| Background | This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016] |
| Synonyms | AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L |
| Reference Data | |
| Protein Families | Druggable Genome, Transcription Factors |
Documents
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Resources
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