Caldesmon (CALD1) Mouse Monoclonal Antibody [Clone ID: OTI3E8]

Specifications

Product Data
Clone Name	OTI3E8
Applications	IHC
Recommend Dilution	IHC 1:1200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 220-450 human Caldesmon (NP_149129) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1.00mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
Predicted Protein Size	93.2 kDa
Gene Name	caldesmon 1
Database Link	NP_149129 Entrez Gene 800 Human UniProt ID Q05682
Background	This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Synonyms	CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Reference Data
Protein Pathways	Vascular smooth muscle contraction

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