HIRA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human HIRA
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	1.65 mg/ml
Purification	Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	111.7 kDa
Gene Name	histone cell cycle regulator
Database Link	NP_003316 Entrez Gene 15260 MouseEntrez Gene 363849 RatEntrez Gene 7290 Human UniProt ID P54198
Background	This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Synonyms	DGCR1; TUP1; TUPLE1
Reference Data
Protein Families	Transcription Factors

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