Cytokeratin 8 (KRT8) Mouse Monoclonal Antibody [Clone ID: UMAB1]
CAT#: UM500001CF
Carrier-free (BSA/glycerol-free) KRT8/CK8 mouse monoclonal antibody, clone UMAB1
Formulation: Standard
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CNY 4,999.00
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Specifications
Product Data | |
Clone Name | UMAB1 |
Applications | 10k-ChIP, IF, IHC, WB |
Recommend Dilution | WB 1:500~1000, IHC 1:50, IF 1:50~100 |
Reactivity | Human, Monkey, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 91-381 of human CK8 (NP_002264) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 53.5 kDa |
Gene Name | keratin 8 |
Database Link | |
Background | Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. |
Synonyms | CARD2; CK-8; CK8; CYK8; K2C8; K8; KO |
Reference Data | |
Protein Families | Druggable Genome |
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