Her2 (ERBB2) Mouse Monoclonal Antibody [Clone ID: UMAB36]
CAT#: UM500036
Purified HER2 (ERBB2) mouse monoclonal antibody,clone UMAB36
View other "UMAB36" antibodies (2)
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CNY 2,999.00
Cited in 11 publications. |
CNY 4,840.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 9,998.00
Specifications
Product Data | |
Clone Name | UMAB36 |
Applications | 10k-ChIP, IF, IHC, WB |
Recommend Dilution | WB:1:500, IHC:1:50, IF:1:100 |
Reactivity | Human, Mouse, Rat, Monkey |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 676-1255 of human ERBB2(NP_004439) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 137.7 kDa |
Gene Name | erb-b2 receptor tyrosine kinase 2 |
Database Link | |
Background | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] |
Synonyms | CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
Protein Pathways | Adherens junction, Bladder cancer, Calcium signaling pathway, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer |
Citations (11)
The use of this Antibodies has been cited in the following citations: |
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Dual-label time-resolved fluoroimmunoassay for simultaneous measurement of human epidermal growth factor receptor 2 and human epididymis protein 4 in serum
,Zhang, Y;Wang, K;Zhao, Y;Fan, J;Han, T;Si, Y;Zhou, B;Zhang, J;Hu, Z;Xie, M;,
J Anal Sci Technol
[ERBB2]
|
PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 32929011
[ERBB2]
|
ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain
,Mitchell, R;Mikolajczak, M;Kersten, C;Fleetwood-Walker, S;,
Neurobiol. Dis.
,PubMed ID 32531343
[ERBB2]
|
Non-Invasive Monitoring of HER2 Expression in Breast Cancer Patients with 99mTc-Affibody SPECT/CT
,Cai, J;Li, X;Mao, F;Wang, P;Luo, Y;Zheng, K;Li, F;Zhu, Z;,
Iran J Radiol
[ERBB2]
|
Prediction model of lymphovascular invasion based on clinicopathological factors in Chinese patients with invasive breast cancer
,Shen, S;Wu, G;Xiao, G;Du, R;Hu, N;Xia, X;Zhou, H;,
Medicine
,PubMed ID 30412123
[ERBB2]
|
Functional role of RRS1 in breast cancer cell proliferation
,Song, J;Ma, Z;Hua, Y;Xu, J;Li, N;Ju, C;Hou, L;,
J. Cell. Mol. Med.
,PubMed ID 30320499
[ERBB2]
|
Programmed death-1 and PD-1 ligand-1 expression in early onset gastric carcinoma and correlation with clinicopathological characteristics
,Wei, P;Jin, M;Zhou, X;Hu, X;Wang, Y;,
Int J Clin Exp Pathol
[ERBB2]
|
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease
,Wang, BJ;Her, GM;Hu, MK;Chen, YW;Tung, YT;Wu, PY;Hsu, WM;Lee, H;Jin, LW;Hwang, SL;Chen, RP;Huang, CJ;Liao, YF;,
Proc. Natl. Acad. Sci. U.S.A
,PubMed ID 28351972
[ErbB2]
|
Development of a highly specific HER2 monoclonal antibody for immunohistochemistry using protein microarray chips
,Qi L, Zhou L, Lu M, Yuan K, Li Z, Wu G, Huang X, Shen Y, Zhao M, Fu W, Chu B, Wang G, Ren F, Ma D, Chen J.,
Biochem. Biophys. Res. Commun.
,PubMed ID 28111342
[ERBB2]
|
A screen of breast and colon cancers with HER2 antibody clone UMAB36 does not exhibit the cross-reactivity of clone 4B5 with HER4 protein
,Lixin Zhou, Kehu Yuan, Fangfang Ren, Lili Ki, Min Zhou, Wei Fu, Xiaozheng Huang, Rachel M. Gonzalez, Youmin Shu, Yi Shen, Guangli Wang, Donghui Ma, Wei-Wu He, Jian Chen,
AACR 2016 Abstract
[ERBB2]
|
Using Protein Chips to Develop a Highly Specific HER2 Antibody for HER2 Amplification Testing
,Zhou, L;Yuan, K;Qi, L;Li, Z;Wu, G;Huang, X;Shen, Y;,
The FASEB Journal
[ERBB2]
|
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
UM500036CF | Carrier-free (BSA/glycerol-free) Purified HER2 (ERBB2) mouse monoclonal antibody,clone UMAB36 |
CNY 4,999.00 |
|
UM570036 | Purified HER2 (ERBB2) mouse monoclonal antibody,clone UMAB36 |
CNY 1,150.00 |