CPS1 Mouse Monoclonal Antibody [Clone ID: UMAB281]

Specifications

Product Data
Clone Name	UMAB281
Applications	IHC, WB
Recommend Dilution	WB 1:1000, IHC 1:1000
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1367-1506 of human CPS1 (NP_001116105) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	165.65 kDa
Gene Name	carbamoyl-phosphate synthase 1
Database Link	NP_001116105 Entrez Gene 227231 MouseEntrez Gene 497840 Rat UniProt ID P31327
Background	The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.[provided by RefSeq, May 2010].
Synonyms	CPSASE1; GATD6; PHN
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways, Nitrogen metabolism

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