Mouse TREM-1 ELISA Kit
CNY 5,000.00
货期*
3周
规格
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Specifications
Product Data | |
Description | Mouse TREM-1 ELISA Kit |
Size | 1 x 96 wells |
Assay Type | Sandwich ELISA kit of Quantitative Detection for Mouse TREM-1 |
Assay Length | 3.5 hours incubations; 1 hour washing and analyzing samples |
Signal | Colorimetric |
Curve Range | 31.2pg/ml-2000pg/ml |
Sample Type | Cell culture supernates, serum and plasma(heparin, EDTA), Cell lysates and tissue homogenates. |
Sample Volume | 100 ul |
Specificity | This kit is used for quantitative detection of mouse TREM-1 |
Sensitivity | <10pg/ml |
Reactivity | Mouse |
Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
Interference | No significant interference observed with available related molecules. |
Components |
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Background | Trem1, Triggering receptor expressed on myeloid cells-1, is encoded by Trem1 gene. The expression of Trem1 is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. Trem1 is a 30-kD glycoprotein that is reduced to 26 kD by deglycosylation, in agreement with the predicted molecular mass. The Trem1 gene which contains 4 exons maps to chromosome 6p21.1, within a TREM gene cluster and the mouse Trem1 gene maps to chromosome 17 in a region that shows homology of synteny to human chromosome 6. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide(LPS), gram-negative bacteria, and fungi. Cross-linking of Trem1 on neutrophils induces interleukin-8(IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1(MCP1, or SCYA2) and tumor necrosis factor(TNF); MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Trem1 engagement also induces upregulation of adhesion molecules(e.g., ITGB1) and costimulatory molecules(e.g., CD40). Trem1 is associated with DAP12(TYROBP), a molecule frequently associated with activating receptors. |
Gene Symbol | Trem1 |
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