Human IL-12 HS ELISA Kit, 1 x 48-well (pre-coated)

Specifications

Product Data
Description	Human IL-12 HS ELISA Kit, 1 x 48-well (pre-coated)
Size	1 x 48 wells (pre-coated)
Format	1 x 48-well (pre-coated)
Assay Type	Solid Phase Sandwich ELISA
Assay Length	4h00min
Signal	Colorimetric
Curve Range	0.78-25 pg/ml
Sample Type	Serum, Plasma, Cell culture supernatant
Sample Volume	100 µl
Specificity	Recognizes both natural and recombinant human IL-12. Specific to p70 heterodimer.
Sensitivity	0.75 pg/ml
Cross Reactivity	No cross reactivity with other human cytokines
Interference	No significant interference observed with available related molecules.
Components	High Sensitivity ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents, and a detailed procedure.
Background	This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Gene Symbol	IL12B
Standard Curve	Representative Standard Curve

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