Human DKK4 ELISA KIT (1 x 96 wells)
CAT#: EA102233
For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA).
CNY 5,330.00
货期*
3周
规格
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Specifications
Product Data | |
Description | For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA). |
Size | 1 x 96 wells |
Format | 8x12 divisible strips |
Assay Type | Sandwich ELISA kit of Quantitative Detection for Human DKK-4 |
Assay Length | 3.5 hours incubations; 1 hour washing and analyzing samples |
Signal | Colorimetric |
Curve Range | 156pg/ml-10000pg/ml |
Specificity | This kit is used for quantitative detection of Human DKK-4 |
Sensitivity | <10pg/ml |
Reactivity | Human |
Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
Components |
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Background | DKK4 is a membersof the Dickkopf family which are negative regulators of the growth-promoting Wnt / beta-catenin signaling pathway. By FISH, the DKK4 gene was mapped to chromosome 8p11.2-p11.1. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. The expression of DKK4 was significantly reduced in hepatocellular carcinomas (HCCs), particularly in HCCs that showed cytoplasmic beta- catenin accumulation. DKK4 expression was also reduced in HCC cell lines. Ectopic expression of DKK4 in 2 HCC cell lines reduced beta-catenin and cyclin D1 protein levels and attenuated beta-catenin activity in reporter gene assays. |
Gene Symbol | DKK4 |
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