Human AKR1C3 ELISA KIT (1 x 96 wells)
CAT#: EA102593
For quantitative detection of human AKR1C3 in cell culture supernates, serum and plasma (heparin, EDTA).
CNY 5,000.00
货期*
3周
规格
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Specifications
Product Data | |
Description | For quantitative detection of human AKR1C3 in cell culture supernates, serum and plasma (heparin, EDTA). |
Size | 1 x 96 wells |
Format | 8x12 divisible strips |
Assay Type | Sandwich ELISA kit of Quantitative Detection for Human AKR1C3 |
Assay Length | 3.5 hours incubations; 1 hour washing and analyzing samples |
Signal | Colorimetric |
Curve Range | 156 pg/ml-10.000pg/ml |
Specificity | This kit is used for quantitative detection of Human AKR1C3 |
Sensitivity | <10pg/ml |
Reactivity | Human |
Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
Components |
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Background | Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene. It is mapped to 10p15.1. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. |
Gene Symbol | AKR1C3 |
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