TMEM111 (EMC3) (NM_018447) Human 3' UTR Clone

Specifications

Product Data
Product Name	TMEM111 (EMC3) (NM_018447) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	POB; TMEM111
ACCN	NM_018447
Insert Size	1417 bp
Sequence Data	Insert Sequence (showhide) >SC201316 3’UTR clone of NM_018447 The sequence shown below is from the reference sequence of NM_018447. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAAAAGGAATTACAGACCTCTATTTTTTGAAGACCGAGCAGGGATTAGCTGTGTCAGGAACTTGGAGTT GCACTTAACCTTGTAACTTTGTTTGGAGCTGGCACCTCTTGAAATAAAAAGGAGGATGCACGAGCTGGC AGGCATGCAGCAAGGCTTGTTCTTGTCTGGGCTGGGTTCCCCTTTATGTTTGAAACTAGAGGAAATAGG AGTATGCTGGGCAACTTGTTATTTTTAAAATGTTGTAAATGTTCCTTCTGGTGACTCTAGTAATGAAAG TCAGAGAAAGGGGGAAACCTCAGGCTACTGATAATATATAAAATCTTGGCCAGGCGCAGTGGCTCACGC CTGTAATCCCAGGATTTTGGGAGGCTGAGGCGGGTGGGTCACGAGATCAGGAGTTCAAGATCAGCCTGG CCAAGATGGTGAAACCCCATCTCTACTAAAAATACAAAAAAAAATTAGCCGGGCGTGGTGGTGGGCACC TGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAGAACTGCTTAAACCTAGGAGGCGGAGGATGCAGTGA GCTGACATCGTGCCACTGCGCTCCAGCCTGGGCGACAGAGCAAAACTCCATCTGAAAAAAAAAAAAAAA TATATATATATATATATATATATCTATCTTAGCAGAAGCCCAGTCTTCGAAGGAAGCATTGTTAATTAT AGCTAATGATTATGTGCAGTCAGCCTGACATCTAGCCACAGTAAACTCCTGTTTTCTTGGGATCCAAAC ACCCTGTGTTTTACCATTAGTTTTGTTAGTATTGTTAACTTTCTTTACACAAGTAAACCATTTCCACTA CCAAAGGTTTAGAAACTATGGATGAACAAAATGAATCTCCCTGTTCATTTTGAGCCTACATAGACATAG AGACCAAATATGTCAAAACCTTATTCAAATAAACTCTCTTCAGAGTGAATACCCAGGGTCAGGACAGAC TCAGCAAACCTTCTATATCACTTAATTCTGCCCAGTGAAAATCAGTGACCCTGAGGCACTGCCAGATTC TAAAGTGCCTTTGGGATCATCAGAGACTGTCTATAAATAATGCAAAATCTTGATCTGGATGTCAGTGTA TCAAATCTTATCAAATCCATTGACAAATCAGTGGTGCTATACTGGAAATGGCTACTCCTTTGGATGAAG GACCTCATTTCCCAGTTGCTTGGAACAAAAGAGAATTTACATATTGCTGTAAGAAGGGAGAGACGGCAG TTGTTGGTAGACACACAGATAAGGGTGCCCAAGAATAATTCTGTCTGGATTAAAGGTCCCAGGGAAGTG ACGGTGCCATTTCTGTACCAAGAGGTGAATATAATTTGCATGTTGAGTGCAGTAATTAAGAACAAACGA CTCGACTCCACAAATTAAACCGTCCTGTTTTCTCTTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_018447.4
Synonyms	POB; TMEM111
Summary	Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).[UniProtKB/Swiss-Prot Function]
Locus ID	55831
MW	54.2

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