TGF beta 1 (TGFB1) (NM_000660) Human 3' UTR Clone

Specifications

Product Data
Product Name	TGF beta 1 (TGFB1) (NM_000660) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta
ACCN	NM_000660
Insert Size	759 bp
Sequence Data	Insert Sequence (showhide) >SC201611 3’UTR clone of NM_000660 The sequence shown below is from the reference sequence of NM_000660. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATGATCGTGCGCTCCTGCAAGTGCAGCTGAGGTCCCGCCCCGCCCCGCCCCGCCCCGGCAGGCCCGGCC CCACCCCGCCCCGCCCCCGCTGCCTTGCCCATGGGGGCTGTATTTAAGGACACCCGTGCCCCAAGCCCA CCTGGGGCCCCATTAAAGATGGAGAGAGGACTGCGGATCTCTGTGTCATTGGGCGCCTGCCTGGGGTCT CCATCCCTGACGTTCCCCCACTCCCACTCCCTCTCTCTCCCTCTCTGCCTCCTCCTGCCTGTCTGCACT ATTCCTTTGCCCGGCATCAAGGCACAGGGGACCAGTGGGGAACACTACTGTAGTTAGATCTATTTATTG AGCACCTTGGGCACTGTTGAAGTGCCTTACATTAATGAACTCATTCAGTCACCATAGCAACACTCTGAG ATGCAGGGACTCTGATAACACCCATTTTAAAGGTGAGGAAACAAGCCCAGAGAGGTTAAGGGAGGAGTT CCTGCCCACCAGGAACCTGCTTTAGTGGGGGATAGTGAAGAAGACAATAAAAGATAGTAGTTCAGGCCA GGCGGGGTGGCTCACGCCTGTAATCCTAGCACTTTTGGGAGGCAGAGATGGGAGGATTACTTGAATCCA GGCATTTGAGACCAGCCTGGGTAACATAGTGAGACCCTATCTCTACAAAACACTTTTAAAAAATGTACA CCTGTGGTCCCAGCTACTCTGGAGGCTAAGGTGGGAGGATCACTTGATCCTGGGAGGTCAAGGCTGCAG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000660.7
Synonyms	CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Locus ID	7040
MW	27

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