LYAR (NM_017816) Human 3' UTR Clone

Specifications

Product Data
Product Name	LYAR (NM_017816) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ZC2HC2; ZLYAR
ACCN	NM_017816
Insert Size	219 bp
Sequence Data	Insert Sequence (showhide) >SC202298 3' UTR clone of NM_017816 The sequence shown below is from the reference sequence of NM_017816. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC GTTATTAAAGGACAAAGTCAAGCTTGTGAAATGAACATTTGTGTATTTAAAAATTGAATCCATTCTGCTG ACTTCTTCCTTTCACTGCTGTTTATAAAATGTGTAATGAATTCTAACAACTCAAATTTTGCTTTTTGAAG CTGTATTTTTAAGTTAAGAAAATATATTTTTGGTATAACTTTTATGAGAAAAATAAAATATATTCTGGTC CAAACTTCT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017816.2
Synonyms	ZC2HC2; ZLYAR
Summary	Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	55646

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