Glutathione Peroxidase 1 (GPX1) (NM_000581) Human 3' UTR Clone
CAT#: SC202736
3' UTR clone of glutathione peroxidase 1 (GPX1) transcript variant 1 for miRNA target validation
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CNY 4,845.00
货期*
3周
规格
Cited in 1 publication. |
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经常一起买 (2)
Specifications
Product Data | |
Product Name | Glutathione Peroxidase 1 (GPX1) (NM_000581) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | GPXD; GSHPX1 |
ACCN | NM_000581 |
Insert Size | 242 bp |
Sequence Data |
>SC202736 3’UTR clone of NM_000581
The sequence shown below is from the reference sequence of NM_000581. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTGCTGTCTCAAGGGCCCAGCTGTGCCTAGGGCGCCCCTCCTACCCCGGCTGCTTGGCAGTTGCAGTGC TGCTGTCTCGGGGGGGTTTTCATCTATGAGGGTGTTTCCTCTAAACCTACGAGGGAGGAACACCTGATC TTACAGAAAATACCACCTCGAGATGGGTGCTGGTCCTGTTGATCCCAGTCTCTGCCAGACCAAGGCGAG TTTCCCCACTAATAAAGTGCCGGGTGTCAGCAGAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_000581.4 |
Synonyms | GPXD; GSHPX1 |
Summary | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017] |
Locus ID | 2876 |
MW | 8.6 |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells
,La Sala, L;Cattaneo, M;De Nigris, V;Pujadas, G;Testa, R;Bonfigli, AR;Genovese, S;Ceriello, A;,
Cardiovasc Diabetol
,PubMed ID 27137793
[Glutathione Peroxidase 1]
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