DHX58 (NM_024119) Human 3' UTR Clone

Specifications

Product Data
Product Name	DHX58 (NM_024119) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	D11LGP2; D11lgp2e; LGP2; RLR-3
ACCN	NM_024119
Insert Size	380 bp
Sequence Data	Insert Sequence (showhide) >SC204998 3’UTR clone of NM_024119 The sequence shown below is from the reference sequence of NM_024119. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGAACTTGTCGGACCTCTCCCTGGACTGACCACCTCATTGCTGCAGTGCCCGGTTTGGGCTGTAGGGG GCGGGAGAGTCTGCAGCAGACTCCAGGCCCCTCCTTCCTGAATCATCAGCTGTGGGCATCAGGCCCACC AGCCACACAGGAGTCCTGGGCACCCTGGCTTAGGCTCCCGCAATGGGAAAACAACCGGAGGGCCAGAGC TTAGTCCAGACCTACCTTGTACGCACATAGACATTTTCATATGCACTGGATGGAGTTAGGGAAACTGAG GCAAAAGAATTTGCCATACTGTACTCAGAATCACGACATTCCTTCCCTACCAAGGCCACTTCTATTTTT TGAGGCTCCTCATAAAAATAAATGAAAAAATGGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_024119.3
Synonyms	D11LGP2; D11lgp2e; LGP2; RLR-3
Summary	Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.[UniProtKB/Swiss-Prot Function]
Locus ID	79132
MW	13.5

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