RAN (NM_006325) Human 3' UTR Clone

Specifications

Product Data
Product Name	RAN (NM_006325) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ARA24; Gsp1; TC4
ACCN	NM_006325
Insert Size	1782 bp
Sequence Data	Insert Sequence (showhide) >SC205001 3’UTR clone of NM_006325 The sequence shown below is from the reference sequence of NM_006325. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCTCTCCCGGATGAGGATGATGACCTGTGAGAATGAAGCTGGAGCCCAGCGTCAGAAGTCTAGTTTTAT AGGCAGCTGTCCTGTGATGTCAGCGGTGCAGCGTGTGTGCCACCTCATTATTATCTAGCTAAGCGGAAC ATGTGCTTCATCTGTGGGATGCTGAAGGAGATGAGTGGGCTTCGGAGTGAATGTGGCAGTTTAAAAAAT AACTTCATTGTTTGGACCTGCATATTTAGCTGTTTTGGAACGCAGTTGATTCCTTGAGTTTCATATATA AGACTGCTGCAGTCACATCACAATATTCAGTGGTGAAATCTTGTTTGTTACTGTCATTCCCATTCCTTT TCGTTTAGAATCAGAATAAAGTTGTATTTCAAATATCTAAGCAAGTGAACTCATCCCTTGTTTATAAAT AGCATTTGGAAACCACTAAAGTAGGGAAGTTTTATGCCATGTTAATATTTGAATTGCCTTGCTTTTATC ACTTAATTTGAAATCTATTGGGTTAATTTCTCCCTATGTTTATTTTTGTACATTTGAGCCATGTCACAC AAACTGATGATGACAGGTCAGCAGTATTCTATTTGGTTAGAAGGGTTACATGGTGTAAATATTAGTGCA GTTAAGCTAAAGCAGTGTTTGCTCCACCTTCATATTGGCTAGGTAGGGTCACCTAGGGAAGCACTTGCT CAAAATCTGTGACCTGTCAGAATAAAAATGTGGTTTGTACATATCAAATAGATATTTTAAGGGTAATAT TTTCTTTTATGGCAAAAGTAATCATGTTTTAATGTAGAACCTCAAACAGGATGGAACATCAGTGGATGG CAGGAGGTTGGGAATTCTTGCTGTTAAAAATAATTACAAATTTTGCACTTTTTTGTTTGAATGTTAGAT GCTTAGTGTGAAGTTGATACGCAAGGAAAATGGTCCATGTTTACCCACAGTTTTCAGGTACTCCTAGAC TTTAAAGATGTCTTGAACATTTAAGTTCTTCAGCAGTTCACACTACACCGTTTTTTTGTTTTTTTTTCC CCCCCGGGAGGGTTTTTTTGTAGGGCAGCACAGCAGAGCAGGACATGGATGAAATACTAGGAATATGCA CAGTGGGGCAGTGTGGGGGCTTCTCAGTAATGGAGAACAGTTGGTGAAACTTTTTTTTTTTTTTAACTA AGCATTTAATTTATCTTGCATATTTTCCACATTTAAAAATGAATTAGGTCTATTAGGATAATTAGGAGT TTGATCCCATCAACACTATTCTTGTAGCAGTTAGGAATCTTGAGCTATTTTTTTCTCATACGATTACTA TAGTCCAGTTTACCAAAGTTTTCTTTAGATGTCTGATAATCTTGAGATGATTGCTTACCTTAAAAGGTA TAGAAAGGATCACTTAAATATATGGAAAAATGAAATAAGGGTGAAGCTGAATAAAGTTCTACTTACTGT ATTAACTGGCAACAGTTGAGTTTCTTAAGATCTGAATTGCTGTGTATGTTACGCTGTATTCAGAACCAG TTTCTAACCAGCCTGTGAGATGGGAAGTTTTTTCCCCATAATTGGGATGAAACCTTTCATTCAGGTATT TTGAATTGAAGGTGTATGTGTTGTTTGTAACCTTGTGGAGATTGCAAGTGGTGTTGACATTCTGGATCT TCTATGTAACAGTTGAAATTTGGAAGTGACGTCACTTACCTGTCTAACGTGGTGTGGGAGAGAATTTAC AAGTCCTTTATTGAAAGAATAATTGTTGCAAAATATATTGCTTCTACTTTGCCTGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006325.5
Synonyms	ARA24; Gsp1; TC4
Summary	RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
Locus ID	5901
MW	69.2

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