Cullin 2 (CUL2) (NM_003591) Human 3' UTR Clone
CAT#: SC206235
3' UTR clone of cullin 2 (CUL2) for miRNA target validation
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CNY 4,845.00
货期*
3周
规格
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经常一起买 (2)
Specifications
Product Data | |
Product Name | Cullin 2 (CUL2) (NM_003591) Human 3' UTR Clone |
Vector | pMirTarget |
ACCN | NM_003591 |
Insert Size | 1790 bp |
Sequence Data |
>SC206235 3’UTR clone of NM_003591
The sequence shown below is from the reference sequence of NM_003591. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCGGCAGATGAATACAGCTACGTCGCGTGATGTCGCTCTCCTCCAGCGTGGTGTGAGAAGATCATTGCC ATCACCATTTGGTGTGTTCCTGTGGGAAAAAGCAGGACTGTGCCTCCATAATTTGGTCATTTGGCAGCC CCTGTTTTCTGCTGTTTACAACATCACCAGTGCCACGTCATGAGCGTCAAAGAAAATGCCTAGAGATAT TTCAAGCTCATGTCATTATGACATTTCTTAAAACTTTATTAAAAGAATGAGTGAAGTATTGCTGAAAAG TGGAAATTCGGTTGGGTACCATGCTTTTTCTCCCCTTCACGTTTGCAGTTGATGTGTCTTTTTTTTTTT TTTTAATGTATCTTAAAGGACATAAAATTTAAAAACTTAAATATTGTAATATGACAGATAACCTAATAA TTGTATCTACATTAAAATGACAAACATGATACTGCTGCTTGTCAAATAAAAAAAAAATAAAGAAATAGA ATGCCTTTTTTATGTGGATGGAGTATCAGGTTGACCACAAAATATATTGACTCAAAGCAGCTAATGCAT CTTTAGTTGCGTTTTTATCTGAATGGTTTAATTCACTTGTACTCCTATTTAAATCCTACATGAAAAATG TCTAGATTATTGTTCTTGACTGCATAGGACTGCATTCAGCATAAAGAATGCTTTATTTTTATGGATTAG ATATATTGGATCTAAACATTTTGAATCTTGAAGATGTAATTCCATCAGCAGTTTCTGGTGGTGTGCTAC TCCACAGACATCGCAGAGTGTGAGCAGGATGCTTGGTGACCTCAAGTCTGGCACAGAGAGAGCTTTTCA TTCAAAAGTTGTCTTTCTTCGGTTGCATAATCCATTAATTCTAGCATAGACTAGTACCCTAGCTCTGTG GCCTTCCCTGAGTCTTAGGAAATCTATGATACCAACATATTCCTTCTATATGCCTCCCCTACCTGTTAC CCTTACAACCCTCCTCCAACAGTTTAGATACTAGAGTCACTCTCATCAATCACAGATGTGCTTAGCAAT GCATAACCTAAATACTTTTTTAAAAAAGAAAATTGTACATTGTACTGGGTGCCACATATATAAATCCCA TTATTTTGTTTATTTTATATATATATATATATATAATATATATATATATATATCTCAACAGCAGTGTTA AGAGTACTGCGATCTATTATCATATTTATTGTCTATCCACACCATCACCACCACCACCACACCCCTCCT CCCTCAACATACAATTTTTCTTTATTTTAAAAAAAATAAGAGACGGGGTTTCGCCATGTTTCCCAGGCT AGTCTGGAACTTCTGGCCTCAAGCAATCCTATCTCTGTCTCCCAAAGTGCTGGGATTACAAGCATGAGC CACTGCATCCATCCAACACAAAATTTTTAAAATCGGAATATTTTAAAGCAAATCACACAAATTATTTCA CTTATAATACTTCAGTAAGGCCTTTAAAAAATCCACAGTGATATTATTACTCCTAACAAAAACAATAAT TACTTAGTATCATCTAATATGTGGTTCATATTTAAATTTGTTGTTTTGAGATGGGTCTTACAATTGGTT TATTCAATTGCATTTTTTCTAACTCGTGTCTCAAGTGTTTTAAAAATCTACTGAACTTATAATGACTTA TATAATGTATTTCTCATTTTACCTTTCTTCCAAAAGAGGAAATAATGGCAAACCATATAATATTGTACA TTCACTGTCAAAAAGCAAACCCTTGTTTTGATAACTTGTTGATTGATAAAAGTTTTCCAAATTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_003591.4 |
Summary | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).[UniProtKB/Swiss-Prot Function] |
Locus ID | 8453 |
MW | 70.1 |
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