Metabotropic Glutamate Receptor 2 (GRM2) (NM_000839) Human 3' UTR Clone

Specifications

Product Data
Product Name	Metabotropic Glutamate Receptor 2 (GRM2) (NM_000839) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GLUR2; GPRC1B; mGlu2; MGLUR2
ACCN	NM_000839
Insert Size	531 bp
Sequence Data	Insert Sequence (showhide) >SC207135 3’UTR clone of NM_000839 The sequence shown below is from the reference sequence of NM_000839. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGGTGGACTCGACAACGTCATCGCTTTGAAGACCCCATACTCCCGCCCTGACACAGCTGCTCCTGGGA ACCTAGTGCAGACCCACGTCCAGGGCCAGGAGGAAGTTGGCTGGAGCACTGCAATAATTTATTACCCAC CCTATGTCTGCCCCCAAAGTCACTTACCCACCTCCTTACCCCAGCTCTTCAGACTCAGAAGTCAGGAGC CTTGGCCAGGAGCCTCTGCAGTGGCCACTAACTGCCCTTGTAGCTGTGTTTCCTCCTGGCCAGGCCCAG GGCTCAGAGAGGAGCAAGCCAGGGTTCACTCTGCCCTGGACCCGGGTGGCTGAGGACGGCAGGCCCCAG TCCTAACCAGCAAAGGTGCTTCCAGCCCAGCCCCTCCCCCCAACTAGGGCCTTTTTTATTTTTTATATA AGTTACTCTGGGATGGGGAGGGTGGTTATTGTGGGGGCTGCCCCTCCCCCTGCACAGTAGTTTGTCCTG TGGTTTATTTTGTATTACCTGTAAATAAAGTGGCTTTATTTTAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000839.5
Synonyms	GLUR2; GPRC1B; mGlu2; MGLUR2
Summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Locus ID	2912
MW	19.6

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