Metabotropic Glutamate Receptor 8 (GRM8) (NM_001127323) Human 3' UTR Clone

Specifications

Product Data
Product Name	Metabotropic Glutamate Receptor 8 (GRM8) (NM_001127323) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GLUR8; GPRC1H; mGlu8; MGLUR8
ACCN	NM_001127323
Insert Size	619 bp
Sequence Data	Insert Sequence (showhide) >SC207825 3’UTR clone of NM_001127323 The sequence shown below is from the reference sequence of NM_001127323. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCGATGGTCAAGAGCGGGAGCACTTCCTAATAGATCTTCCTCTACCAAGACAACATATATCAGTTACAG CAATCATTCAATCTGAAACAGGGAAATGGCACAATCTGAAGAGATGTGGTATATGATCTTAAATGATGA ACATGAGACCGCAAAAATTCACTCCTGGAGATCTCCGTAGACTACAATCAATCAAATCAATAGTCAGTC TTGTAAGGAACAAAAATTAGCCATGAGCCAAAAGTATCAATAAACGGGGAGTGAAGAAACCCGTTTTAT ACAATAAAACCAATGAGTGTCAAGCTAAAGTATTGCTTATTCATGAGCAGTTAAAACAAATCACAAAAG GAAAACTAATGTTAGCTCGTGAAAAAAAATGCTGTTGAAATAAATAATGTCTGATGTTATTCTTGTATT TTTCTGTGATTGTGAGAACTCCCGTTCCTGTCCCACATTGTTTAACTTGTATAAGACAATGAGTCTGTT TCTTGTAATGGCTGACCAGATTGAAGCCCTGGGTTGTGCTAAAAATAAATGCAATGATTGATGCATGCA ATTTTTTATACAAATAATTTATTTCTAATAATAAAGGAATGTTTTGCAAATGTTAAAAAAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001127323.1
Synonyms	GLUR8; GPRC1H; mGlu8; MGLUR8
Summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Locus ID	2918
MW	23.6

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