HSD11B2 (NM_000196) Human 3' UTR Clone

Specifications

Product Data
Product Name	HSD11B2 (NM_000196) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AME; AME1; HSD2; HSD11K; SDR9C3
ACCN	NM_000196
Insert Size	580 bp
Sequence Data	Insert Sequence (showhide) >SC207992 3’UTR clone of NM_000196 The sequence shown below is from the reference sequence of NM_000196. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCGGCCCTTCCCCAGCAGTGGCTCGGTGAGCCATGTGCACCTATGGCCCAGCCACTGCAGCACAGGAG GCTCCGTGAGCCCTTGGTTCCTCCCCGAAAACCCCCAGCATTACGATCCCCCAAGTGTCCTGGACCCTG GCCTAAAGAATCCCACCCCCACTTCATGCCCACTGCCGATGCCCAATCCAGGCCCGGTGAGGCCAAGGT TTCCCAGTGAGCCTCTGCGCCTCTCCACTGTTTCATGAGCCCAAACACCCTCCTGGCACAACGCTCTAC CCTGCAGCTTGGAGAACTCCGCTGGATGGGGAGTCTCATGCAAGACTTCACTGCAGCCTTTCACAGGAC TCTGCAGATAGTGCCTCTGCAAACTAAGGAGTGACTAGGTGGGTTGGGGACCCCCTCAGGATTGTTTCT CGGCACCAGTGCCTCAGTGCTGCAATTGAGGGCTAAATCCCAAGTGTCTCTTGACTGGCTCAAGAATTA GGGCCCCAACTACACACCCCCAAGCCACAGGGAAGCATGTACTGTACTTCCCAATTGCCACATTTTAAA TAAAGACAAATTTTTATTTCTTCTAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000196.4
Synonyms	AME; AME1; HSD2; HSD11K; SDR9C3
Summary	There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Locus ID	3291
MW	20.6

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