P Glycoprotein (ABCB1) (NM_000927) Human 3' UTR Clone
CAT#: SC208086
3' UTR clone of ATP-binding cassette sub-family B (MDR/TAP) member 1 (ABCB1) for miRNA target validation
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CNY 4,845.00
货期*
3周
规格
Cited in 1 publication. |
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经常一起买 (2)
Specifications
Product Data | |
Product Name | P Glycoprotein (ABCB1) (NM_000927) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1 |
ACCN | NM_000927 |
Insert Size | 1256 bp |
Sequence Data |
>SC208086 3’UTR clone of NM_000927
The sequence shown below is from the reference sequence of NM_000927. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGTGTCCAGGCTGGAACAAAGCGCCAGTGAACTCTGACTGTATGAGATGTTAAATACTTTTTAATATTT GTTTAGATATGACATTTATTCAAAGTTAAAAGCAAACACTTACAGAATTATGAAGAGGTATCTGTTTAA CATTTCCTCAGTCAAGTTCAGAGTCTTCAGAGACTTCGTAATTAAAGGAACAGAGTGAGAGACATCATC AAGTGGAGAGAAATCATAGTTTAAACTGCATTATAAATTTTATAACAGAATTAAAGTAGATTTTAAAAG ATAAAATGTGTAATTTTGTTTATATTTTCCCATTTGGACTGTAACTGACTGCCTTGCTAAAAGATTATA GAAGTAGCAAAAAGTATTGAAATGTTTGCATAAAGTGTCTATAATAAAACTAAACTTTCATGTGACTGG AGTCATCTTGTCCAAACTGCCTGTGAATATATCTTCTCTCAATTGGAATATTGTAGATAACTTCTGCTT TAAAAAAGTTTTCTTTAAATATACCTACTCATTTTTGTGGGAATGGTTAAGCAGTTTAAATAATTCCTG TTGTATATGTCTATTCACATTGGGTCTTACAGAACCATCTGGCTTCATTCTTCTTGGACTTGATCCTGC TGATTCTTGCATTTCCACATTAAGGTGGCTCTCAAACCCAAAACACAGATCGATATAAGATTTTAGGAG GTGGGGTGAGGCACAATTATGAAGTGCATATTATTCAGATGTATAGTAAATACTTTGCATTGCTTTTAT AAAGGGTTCTTTAAGGATTTTTTAAGATTTTTACACTTCCAAAGTACATTTACTTTTTGTCTTGATAAT GAATCACTTTTGCCAGTAATTGGCCTCTTCCAAAAGTGATCCTTCTGACTTACAGATGTTTAAAATGTG CCATGAGTTTAACTACATCTTGATACAAACATGATAAAAAAAGAAAAAAATATATTCCAAAGGTTGGGA CTCTGGACGACAAATTTTTTTAAATTAGCCAAAAAGCATTATTAACATTATAAACTATATTTACTATAA ACAATTGCTATCTTAAATAAGCAACTTCTAAAAATAAAAAAAAGAAGCCATCACCTCCAGGAAAAAAAA ATAGGAAAGGATATAATCAGGTAATTCTCAAAGAAGAAATGCATGAGAAAAATGTATACAGTTTCAACA ATCAAATAAATGCAAATTAAAACAAAATATCATTTTTTTGCCTTGTAATTTAATGATGAATAAAAAAAT CTAATGTGACATTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_000927.5 |
Synonyms | ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1 |
Summary | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
Locus ID | 5243 |
MW | 49.9 |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Increased Expression of P-Glycoprotein and Doxorubicin Chemoresistance of Metastatic Breast Cancer Is Regulated by miR-298
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The American Journal of Pathology
,PubMed ID 22521303
[P Glycoprotein]
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