P Glycoprotein (ABCB1) (NM_000927) Human 3' UTR Clone

Specifications

Product Data
Product Name	P Glycoprotein (ABCB1) (NM_000927) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1
ACCN	NM_000927
Insert Size	1256 bp
Sequence Data	Insert Sequence (showhide) >SC208086 3’UTR clone of NM_000927 The sequence shown below is from the reference sequence of NM_000927. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGTGTCCAGGCTGGAACAAAGCGCCAGTGAACTCTGACTGTATGAGATGTTAAATACTTTTTAATATTT GTTTAGATATGACATTTATTCAAAGTTAAAAGCAAACACTTACAGAATTATGAAGAGGTATCTGTTTAA CATTTCCTCAGTCAAGTTCAGAGTCTTCAGAGACTTCGTAATTAAAGGAACAGAGTGAGAGACATCATC AAGTGGAGAGAAATCATAGTTTAAACTGCATTATAAATTTTATAACAGAATTAAAGTAGATTTTAAAAG ATAAAATGTGTAATTTTGTTTATATTTTCCCATTTGGACTGTAACTGACTGCCTTGCTAAAAGATTATA GAAGTAGCAAAAAGTATTGAAATGTTTGCATAAAGTGTCTATAATAAAACTAAACTTTCATGTGACTGG AGTCATCTTGTCCAAACTGCCTGTGAATATATCTTCTCTCAATTGGAATATTGTAGATAACTTCTGCTT TAAAAAAGTTTTCTTTAAATATACCTACTCATTTTTGTGGGAATGGTTAAGCAGTTTAAATAATTCCTG TTGTATATGTCTATTCACATTGGGTCTTACAGAACCATCTGGCTTCATTCTTCTTGGACTTGATCCTGC TGATTCTTGCATTTCCACATTAAGGTGGCTCTCAAACCCAAAACACAGATCGATATAAGATTTTAGGAG GTGGGGTGAGGCACAATTATGAAGTGCATATTATTCAGATGTATAGTAAATACTTTGCATTGCTTTTAT AAAGGGTTCTTTAAGGATTTTTTAAGATTTTTACACTTCCAAAGTACATTTACTTTTTGTCTTGATAAT GAATCACTTTTGCCAGTAATTGGCCTCTTCCAAAAGTGATCCTTCTGACTTACAGATGTTTAAAATGTG CCATGAGTTTAACTACATCTTGATACAAACATGATAAAAAAAGAAAAAAATATATTCCAAAGGTTGGGA CTCTGGACGACAAATTTTTTTAAATTAGCCAAAAAGCATTATTAACATTATAAACTATATTTACTATAA ACAATTGCTATCTTAAATAAGCAACTTCTAAAAATAAAAAAAAGAAGCCATCACCTCCAGGAAAAAAAA ATAGGAAAGGATATAATCAGGTAATTCTCAAAGAAGAAATGCATGAGAAAAATGTATACAGTTTCAACA ATCAAATAAATGCAAATTAAAACAAAATATCATTTTTTTGCCTTGTAATTTAATGATGAATAAAAAAAT CTAATGTGACATTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000927.5
Synonyms	ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Locus ID	5243
MW	49.9

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