SLAMF1 (NM_003037) Human 3' UTR Clone

Specifications

Product Data
Product Name	SLAMF1 (NM_003037) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD150; CDw150; SLAM
ACCN	NM_003037
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC208547 3’UTR clone of NM_003037 The sequence shown below is from the reference sequence of NM_003037. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TATGCTAGTGTGACACTTCCAGAGAGCTGACACCAGAGACCAACAAAGGGACTTTCTGAAGGAAAATGG AAAAACCAAAATGAACACTGAACTTGGCCACAGGCCCCAAGTTTCCTCTGGCAGACATGCTGCACGTCT GTACCCTTCTCAGATCAACTCCCTGGTGATGTTTCTTCCACATACATCTGTGAAATGAACAAGGAAGTG AGGCTTCCCAAGAATTTAGCTTGCTGTGCAGTGGCTGCAGGCGCAGAACAGAGCGTTACTTGATAACAG CGTTCCATCTTTGTGTTGTAGCAGATGAAATGGACAGTAATGTGAGTTCAGACTTTGGGCATCTTGCTC TTGGCTGGAACTGGATAATAAAAATCAGACTGAAAGCCAGGACATCTGAGTACCTATCTCACACACTGG ACCACCAGTCACAAAGTCTGGAAAAGTTTACATTTTGGCTATCTTTACTTTGTTCTGGGAGCTGATCAT GATAACCTGCAGACCTGATCAAGCCTCTGTGCCTCAGTTTCTCTCTCAGGATAAAGAGTGAATAGAGGC TGAAGGGTGAATTTCTTATTATACATAAAACACTCTGATATTATTGTATAAAGGAAGCTAAGAATATTA TTTTATTTGCAAAACCCAGAAGCTAAAAAGTCAATAAACAGAAAGAATGATTTTGAGATCTCTGAGTTT TGAACAGTGGACTGGAAACCATGTAAGAGCCTTAAAAGTACAGTTCTGTGCAAATGGCATTCAGTTTTA AAGAAAAACGTAGCAAATGTTTGATGGTGCTGTTACAAAGGAGCTTGGAATACTCAGAGGAACTTGTCC CATGGTGATTTTTCACTTCTCAAAATGATGTTTAAATCCCAGTTCTCTGTTGATTCCCTTGAACAACAA ACCTGGAACCTCAGCTAAGACTCTCTGTGACCAGATTCTGAACCTCTTATATCCAGGGCTTCAAGGGGT ATTGCAGGTCAAGGTCTTTCCTAGGCACTTTCTACTCCCTGCATACCTCTCCTCACACTAAATTTATCC TCTAGTAGAAAATTAAGTTATTTTGGTCTAACAGCTTCAAATCTTTGAATGCTCAATAACTTATTTTGC AAGCTGCAGGCAGAAAGAGACTTTTTAAGTAAAGTCCTTTGTTTTTTCCTATTCTCTGCTTTTAGACAG GCTGTCCTCAATTTAAGCCCTGCTTTTTCTTATTGTTTCTTATATAAACTTGGTAAGTACTGTAAGAAA CAGCCACTATCATACCATTGCATAATAAGGAGCACCAACTTCCCAGCTCAAAACTCAGGTCCTTATTGC CTTGTATCTTACCTCCTCTATGAGGTCAATTCACATTGTAAGCCTGTTGCTTAGTGCATCTCGTTTCCT GGTACCAGCTTCTTTAATAGAGTTCTTAGTTGCAATCAACAGAAGCTGGCTTTGGCTTTTTTATGTAGA AAAGGAACCTATTGAAAAGATACTGATTGGTTCCAATAACTGCTAGAAGTTTCTGCAAAACCATGCTTT GAAAGTGAGCAGGAAAAGAAGAGACTAGGCTGTGGCTGGGAGCACAGCCAAAATTACAAAACCAGCCCA GGGATGATGATCCTGTTCATGCACAGCCACTGTCCCCAGCACTAGGCACAGACTCTACCACTGCCTCAC TGTCTCTGCTGGACTTGGAAACTTGATATTACTGTTACTGCTGCACTGTCTGCCATGAAAATGAATTCT CCAGGGTCCCTTCTTCATCCTTTCATCTCTAGCTTATAATTCAAAGTCTGGGATTGAGTGGCCAATCCT AGGTCACATGTCCATGTCCTATCTCCAAGGGGGGCTGGGAATTGAATATCTGGCATTTTCCACTTTCAC TTCTTATGAATTAAGGAATTCTACAAATAATAGAAGTGGGATTCAGGTGGTAGGCAGACAAAAAAGCCT CACAATTATCCACTACGCCACCCTTGTATAACCTTACCCTCATTCACTGTCTACTCTCAAAACTGTGG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003037.5
Synonyms	CD150; CDw150; SLAM
Summary	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396).[UniProtKB/Swiss-Prot Function]
Locus ID	6504
MW	75.7

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.