TRAF4AF1 (KNSTRN) (NM_033286) Human 3' UTR Clone

Specifications

Product Data
Product Name	TRAF4AF1 (KNSTRN) (NM_033286) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C15orf23; HSD11; SKAP; TRAF4AF1
ACCN	NM_033286
Insert Size	721 bp
Sequence Data	Insert Sequence (showhide) >SC209013 3’UTR clone of NM_033286 The sequence shown below is from the reference sequence of NM_033286. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGGAAATGGAGCAGCTATTAGAAATGTAAGAAGAAGCAAGTGGCCAGATGGCTCCCTCTTGGGCATAA AATCTCAGAGGAAGCTACTTAGGACATCATCTTGGCCATGATCTTCTGGGACTCACCATCTCCAGAATG AAAACAATTTCTACAGTAGACTTAAGGACAGTTTATGCTGAAATGGCAATTCCTCATTTAAGCAAGTTT TCCCAACCTTCAGGTTGGTCAGCCCTCCTGAGCCTCACAGGTGGATAATTGAGGCCTACAAGAGAGGGG AGCCTAGGAGCTTGGATTGACCTTCTAGTCAACCACCTGACTTCAGCACACCATTACAATCGGGAGACT AAACCAACAACCAGAGGATCTAAAATGTCACATTCAGATTTTCAGGAAGAAAATCTTCATTACAGTGGA GCACAAATGTTCCATACAAGACATCATTGAGGAGCCATGCTGTCCCCTTCTAACCTGAAACACATTCTT TCCCATCCTGGTTGGGCTTCTGTACCTCCTTATTAATTTATGAACCTGAAGTTGCTTGAAGTGTTTTGG GCTTAATAAATGGGGTGAAAGTATAGGTAGCAGTAACACCTACATGAAACAATACACCTTGGATCTTTT AATCTAAATTACTTTTCTTTTTTAAGTCTACTTTTAAAATAAATACTTCTGTAAATATTCTGACTGTAA CATTGAGGAATGAAAATAGCCTTTTAACCTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_033286.4
Synonyms	C15orf23; HSD11; SKAP; TRAF4AF1
Summary	Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).[UniProtKB/Swiss-Prot Function]
Locus ID	90417
MW	27.3

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