TRAF2 (NM_021138) Human 3' UTR Clone

Specifications

Product Data
Product Name	TRAF2 (NM_021138) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	MGC:45012; RNF117; TRAP; TRAP3
ACCN	NM_021138
Insert Size	736 bp
Sequence Data	Insert Sequence (showhide) >SC209375 3’UTR clone of NM_021138 The sequence shown below is from the reference sequence of NM_021138. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGGCCATTGTGGACCTGACAGGGCTCTAACTGCCCCCTACTGGTGTCTGGGGGTTGGGGGCAGCCAGG CACAGCCGGCTCACGGAGGGGCCACCACGCTGGGCCAGGGTCTCACTGTACAAGTGGGCAGGGGCCGCG CTTGGGCGCTTGGGAGGGTGTCGGCCTGCAGCCAAGTTCACTGTCACGGGGGAAGGAGCCACCAGCCAG TCCTCAGATTTCAGAGACTGCGGAGGGGCTTGGCAGACGGTCTTAGCCAAGGGCTGTGGTGGCATTGGC CGAGGGTCTTCGGGTGCTTCCCAGCACAAGCTGCCCTTGCTGTCCTGTGCAGTGAAGGGAGAGGCCCTG GGTGGGGGACACTCAGAGTGGGAGCACATCCCAGCAGTGCCCATGTAGCAGGAGCACAGTGGATGGCCT TGTGTCCCTCGGGCATGACAGGCAGAAACGAGGGCTGCTCCAGGAGAAGGGCCTCCTGCTGGCCAGAGC AAGGAAGGCTGAGCAGCTTGGTTCTCCCCTCTGGCCCCTGGAGAGAAGGGAGCATTCCTAGACCCCTGG GTGCTTGTCTGCACAGAGCTCTGGTCTGTGCCACCTTGGCCAGGCTGGCTGTGGGAGAGGGTCTGGTCC CACGCCGCCTCTGCTCAGACCACTGTGTGGGAGGTGCACAGCACAGCCTGCGGGTAAAGTGTGAGAGCT TGCCATCCAGCTCACGAAGACAGAGTTATTAAACCATTCAAATCTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_021138.4
Synonyms	MGC:45012; RNF117; TRAP; TRAP3
Summary	The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
Locus ID	7186
MW	25.9

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