TPX2 (NM_012112) Human 3' UTR Clone

Specifications

Product Data
Product Name	TPX2 (NM_012112) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C20orf1; C20orf2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; p100; REPP86
ACCN	NM_012112
Insert Size	750 bp
Sequence Data	Insert Sequence (showhide) >SC209463 3’UTR clone of NM_012112 The sequence shown below is from the reference sequence of NM_012112. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCAAATTCTCCACTCGATTCCACTGCTAAACTCAGCTGTGAGCTGCGGATACCGCCCGGCAATGGGAC CTGCTCTTAACCTCAAACCTAGGACCGTCTTGCTTTGTCATTGGGCATGGAGAGAACCCATTTCTCCAG ACTTTTACCTACCCGTGCCTGAGAAAGCATACTTGACAACTGTGGACTCCAGTTTTGTTGAGAATTGTT TTCTTACATTACTAAGGCTAATAATGAGATGTAACTCATGAATGTCTCGATTAGACTCCATGTAGTTAC TTCCTTTAAACCATCAGCCGGCCTTTTATATGGGTCTTCACTCTGACTAGAATTTAGTCTCTGTGTCAG CACAGTGTAATCTCTATTGCTATTGCCCCTTACGACTCTCACCCTCTCCCCACTTTTTTTAAAAATTTT AACCAGAAAATAAAGATAGTTAAATCCTAAGATAGAGATTAAGTCATGGTTTAAATGAGGAACAATCAG TAAATCAGATTCTGTCCTCTTCTCTGCATACCGTGAATTTATAGTTAAGGATCCCTTTGCTGTGAGGGT AGAAAACCTCACCAACTGCACCAGTGAGGAAGAAGACTGCGTGGATTCATGGGGAGCCTCACAGCAGCC ACGCAGCAGGCTCTGGGTGGGGCTGCCGTTAAGGCACGTTCTTTCCTTACTGGTGCTGATAACAACAGG GAACCGTGCAGTGTGCATTTTAAGACCTGGCCTGGAATAAATACGTTTTGTCTTTCCCTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_012112.5
Synonyms	C20orf1; C20orf2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; p100; REPP86
Summary	Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).[UniProtKB/Swiss-Prot Function]
Locus ID	22974
MW	28.5

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