GIT2 (NM_139201) Human 3' UTR Clone

Specifications

Product Data
Product Name	GIT2 (NM_139201) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CAT-2; CAT2; PKL
ACCN	NM_139201
Insert Size	1531 bp
Sequence Data	Insert Sequence (showhide) >SC209774 3’UTR clone of NM_139201 The sequence shown below is from the reference sequence of NM_139201. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAAAAGTTGCTTGGAAAAGATGCTAATTAATGAAGAGGAGCAACTACTATTGGTGTATTTTTCACAGAT TGGTGCTTTCTAAATAAAAATTGAAAGTAACTCCTAACATTGAATGGGTTTGCTACTGAAAAAGTAATG ATCTTCTGGTGCAAACAGTTGCTTGTGGACTTAAACCTTGGCACTGGTGGGGAATTTGGTCAGATTTTA CAATCTCTGTCAAAGAGTAGACAGCTGAACTCACACCACACCCAGCTTATAGAATGTCCATGGAAGATG AAGGCGCACCAGAAGGGAAGGACCCTGCGCAGAATGGACGTGGTGAATGGTGTTTAAAATGCCAGATGC CAAAGAGTAACACGATTCCCTGCTGACCCCTTAACTCTAATCCATCCAGCACCATGGAGCAGCCTGCAT GTGAGGAATGGAAGGAGCATTCAGGGCCTCCAAGTGACAGTCTCTAAAATGGGGTGGTGCCAGGCAGAT TAGCATGTTCAAAGCTGACACCACTGAGGTCGTGTTTTTTGGGTGACAAAGCCAAAGGAGAGAAAGGCC AAATATTCCAGCCCTGGCCGAAAGATGATCACTCACCAGACGGAAGCAAGCGTGCTGCGTGGAGCATCC ATGCGAAGATGTCAATTCCATAGATCAATAGGTTTCCAGTTTTCTTCGTGATATGTTAATATAGCAAAC TTACCATGATCCGGTTTTCTCTTTTTTCTTTTTTTTTTTACAAAGTGCTGAATTGTTTGGAATATCAAG AGTATTATGTAATAAAAACTTGTTGATCATAATTTTTCTTGTTGGCTTTTTGGAAAGCAATAGGCGATC TGATTTTTCACAAGCTGAACTTCTGTCTTTCTTGCTTTGCAAAGCAACCCTAGTCATCTTTGTGCTGCT TCCATGGTGTCTGCTGTCATTTTTGGCCTTTACAAATTGCTCAGGGCTCATTTGAAAAGCAAGTTACCT AAATGATGTTTTAATGATCTCGAACTCTTGCTTGAAACAGCCTTAGTAATAATCCAGTGTACAGCTTGC CTGCAAACATTTCCCAGCCCCACCATGACAAATTTTAAAGTGGTTAGACATTTTGTTTTGAGGAAGTCC AAACCACAACTTTTCCACATTCAGAAATGAAGCTATTTAATTTGCTTACGTGATGAAGGGAGTTGATTG TGTTTCACCCAATCCAGAAGAAAGGGTCCTTGTTTGTATTGGCTTTTTACTTTCAGCCCGGCTAGCTGT TACTGTCCTTATTGTTTAAAACTGGTAGTTGTATTCATTTACTTGGTGTTTGCTTTTTCTGCTTGCTGT AAAAAAACACAGTCCCACTGCCAAACATTTCTTTCAGCTTCAAACACTCCAGAGTGAAAATTCGAACCT CAGGAAACAGGCCACAACCAATGTATATCAGGTGCAAACTGGTTCTGAGTACACAGACACTTCCAACCA CTCTTCCTTAAAGAGACGTCCGTCTGCCCGGGGCAGTAGGCCCATGTCCATGTACGAGACCGGATCAGG TCAGAAACCATAT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_139201.3
Synonyms	CAT-2; CAT2; PKL
Summary	This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Locus ID	9815
MW	58.4

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