ATF5 (NM_012068) Human 3' UTR Clone

Specifications

Product Data
Product Name	ATF5 (NM_012068) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ATFX; HMFN0395
ACCN	NM_012068
Insert Size	873 bp
Sequence Data	Insert Sequence (showhide) >SC210467 3’UTR clone of NM_012068 The sequence shown below is from the reference sequence of NM_012068. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCCCGGAGCCAGAGGACCCGTAGCTGCTAGAAGGGCAGGGGTGTGGCTTCTGGGGGCTGGTCTTCAGCT CTGGCGCCTTCATCCCCCTGCCTCTACCTTCATTCCAAACCCCTCTCGGCCGGGTGCAGTGGCTTATGC TTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATCGTTTGAGGCCAGGAGGTCAATACCAGCCT GGGCAACATAGTAAGACCCTGTCTCTATTAAAAAAAAAAAATCAACCCTTCTTCCCCACCAAACCACCC AACTCCTCTCTACTCTTATCCTTTTATCCTCTGTCTCTGCTTATCACCTCTCTTGCGTATTTCTGGATC TCCTTCCCTCCTTTCTCGTCCAAATCATGAAATGTTTGGCCTTAGTCAATGTCTATGCCCGTCACATAA CAGCCGAGGCACCGAGGCCCACAGGGAAGCAGCTGGGAGCTTGGAAACCTGGTCTCTTGAATTTCAAAC CTGGTTTCTTACAGGTGGTTGTCTGGGGTGGGTGGAGTGGCGACAGGATAGAGCTGAAGGACTATGCAA ATGAGGAAGTAAGTCAGGGCGGGCTTTGAGAAGGGGACCCATATCCTACAGGCAAAAAGCAGGCTAGGT GACCTTGGGACACTACGCTAAGGGAGGGAGGCTAAAGGCGGCCAGGTTTGCAGTGCGGGAAGATGAGCA GGCCAGTGGGAGGAGGGGCAGGGCAGGGCTGTAGTTGGTGACTGGGTGTTCATTTTAGCTCTAAGAAAA AAAATCAGTGTTTCGTGAAGGTGTTGGAGAGGGGCTGTGTCTGGGTGAGGGATGGCGGGGTACTGATTT TTTTGGGAGGTTATGAGCAAAAATAAAACGAAACATTTCCTCTGG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_012068.6
Synonyms	ATFX; HMFN0395
Summary	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).[UniProtKB/Swiss-Prot Function]
Locus ID	22809
MW	32.1

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