ADAM17 (NM_003183) Human 3' UTR Clone

CAT#: SC211049

3' UTR clone of ADAM metallopeptidase domain 17 (ADAM17) for miRNA target validation



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CNY 4,845.00


货期*
3周

规格
    • 10 ug

Cited in 5 publications.

Product images

经常一起买 (2)
Firefly luciferase assay kit, 150 assays
    • 1 kit

CNY 1,520.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00

Specifications

Product Data
Product Name ADAM17 (NM_003183) Human 3' UTR Clone
Vector pMirTarget
Synonyms ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE
ACCN NM_003183
Insert Size 1721 bp
Sequence Data
>SC211049 3’UTR clone of NM_003183
The sequence shown below is from the reference sequence of NM_003183. The complete sequence of this clone may contain minor differences, such as SNPs.
Blue=Stop Codon Red=Cloning site

GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG
TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC
CGTGTTGACAGCAAAGAAACAGAGTGCTAATTTAGTTCTCAGCTCTTCTGACTTAAGTGTGCAAAATAT
TTTTATAGATTTGACCTACAAATCAATCACAGCTTGTATTTTGTGAAGACTGGGAAGTGACTTAGCAGA
TGCTGGTCATGTGTTTGAACTTCCTGCAGGTAAACAGTTCTTGTGTGGTTTGGCCCTTCTCCTTTTGAA
AAGGTAAGGTGAAGGTGAATCTAGCTTATTTTGAGGCTTTCAGGTTTTAGTTTTTAAAATATCTTTTGA
CCTGTGGTGCAAAAGCAGAAAATACAGCTGGATTGGGTTATGAATATTTACGTTTTTGTAAATTAATCT
TTTATATTGATAACAGCACTGACTAGGGAAATGATCAGTTTTTTTTTATACACTGTAATGAACCGCTGA
ATATGAGGCATTTGGCATTTATTTGTGATGACAACTGGAATAGTTTTTTTTTTTTTTTTTTTTTTTTGC
CTTCAACTAAAAACAAAGGAGATAAATCTAGTATACATTGTCTCTAAATTGTGGGTCTATTTCTAGTTA
TTACCCAGAGTTTTTATGTAGCAGGGAAAATATATATCTAAATTTAGAAATCATTTGGGTTAATATGGC
TCTTCATAATTCTAAGACTAATGCTCTCTAGAAACCTAACCACCTACCTTACAGTGAGGGCTATACATG
GTAGCCAGTTGAATTTATGGAATCTACCAACTGTTTAGGGCCCTGATTTGCTGGGCAGTTTTTCTGTAT
TTTATAAGTATCTTCATGTATCCCTGTTACTGATAGGGATACATGCTCTTAGAAAATTCACTATTGGCT
GGGAGTGGTGGCTCATGCCTGTAATCCCAGCACTTGGAGAGGCTGAGGTTGCGCCACTACACTCCAGCC
TGGGTGACAGAGTGAGACTCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAATTCACTATCTACAAACCTA
GAATATTTAAAATACAAAGATTGCCTGTTTTCAAACACTATTGAATAAGAGGGTGAGATATTTCTTAAC
AACAACAACAACAAAAAAAACAGGTTGTTTTGAATGTGATGAGCCAGCCAGGAGATAGAATACTACCTG
CCCTTAGGGTTGGGGGCTGTCCCCACAAGACTTGATACTTCAGAAACCCTTTTTATTGACCCACAAGCA
GATATTTGAATTACTTCTTACTTTATTGCTCCAGGATTCTGGATGGGCTGCATTTACTGTGTGAAGGAT
AAAAATCATTAGCCTGGATTCTGATTTCTATAAATTGCCATTAAAAGCTTTTTTTCCCCTAAGAACTGA
AATGTGCTCACCAGCCAAAACATTTTAACTTGTAAATTTTGAGGGCAGTTAACCAAACCTGTGACTAAT
CATATCTCCTCCTACCCCCCATTTCCAAGGACATTTGTTACTCAGATACTTGTTATACTAATACTTGAA
CTTGTACCTTATGGTATTTGCTATCTTTTAACTAGTCATGATATTCTTATACTTTAGTTACACTTTTGG
AATTTGATACAAGGTTGAGTGGGGTGTGTGGGTGTATGTATGAGTGAAACAGTTCTCAAAAGAATGTAA
GAAAAACCATTTTTATAAAATTGTGACTTTTTAAAAACATAGTCTTTGTCATTTATAGAATTAACAAGC
TGCTCAGGGTATATTTTATAGCTGTAGCACTGATATCTGCATTAATAAATACTGTCGAAACACAA
ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA
CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_003183.6
Synonyms ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020]
Locus ID 6868
MW 66.8
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Citations (5)

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