SOCS2 (NM_003877) Human 3' UTR Clone

Specifications

Product Data
Product Name	SOCS2 (NM_003877) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
ACCN	NM_003877
Insert Size	1596 bp
Sequence Data	Insert Sequence (showhide) >SC211879 3’UTR clone of NM_003877 The sequence shown below is from the reference sequence of NM_003877. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TACTTGGAAGAATATAAATTCCAGGTATAAATGTTTCTCTTTTTTTAAACATGTCTCACATAGAGTATC TCCGAATGCAGCTATGTAAAAGAGAACCAAAACTTGAGTGCTCTGGATAACTATATGGAATGCTTTCTA AGAACAGCTGAAGCTAATCTAATTTAAATTTAACAGCTTGAAGAGGTAGCTAGGTGTTTAAAGTTCCTC CAGATACTTTTACCTGAGTGATGCTTCCCTTCCTAAGGCTGACCAAGACCTGTTGATCCTTTTAGATTA AAAATAAAATGTCGCATGTAAAGGCTGAAGTCGCGTTTTATCAGAATGCCTTGCCTTCTTAGGTTCTTT TCCATTATGTCAAAGGTCCAGGCTCCAGTAGGAGAGAAAGAACTCCTCATAGGAATACTGAAGAAGTGG GAAGGAACCAAGCTGACACAGGCCTCACTGCAATTTGATATGCCTGCTGATCAGAGTCTCTTGGGCATT TTATATTTTGCATTCTGATGTACCTAGGAGTTTTGTTAAACAGATGATGTATGTGAGTATTTATCCCAT TTTATGCAATTAACCAAATCAACCAAAAAAAGTGACCATGAAGTCCTGTATTTGTCTTTTTACTACATG TAGGAACTCTCATGTGAATGAGTACTGTAGTAATCCATTCTATGGGAGCCTTATTTCAGAAATATTTCA AACTGGTGCAAATGGAAAAGACTTTCTCTTTTCCTTTAAAGCTAAAGACAAGAATATCATGCTATACAG GTGCAACTCAATCCCCGTTAATAAAAACCAATGTAGGTATAGGCATTCTACCCTTTGAAATAGCTGTGT CCCAACCTGTTGCCATTGATTTTTTGGAAATGGCTTTAGAAATATCCAAGTTGTCCTTGAATTGTCTAA CCATGGACATAAACAGTTGTCTCCCTTCTACTGTGTAGAATACTTTGACTTAATTTTCTTCCAGATACA GGGGGATACCTGCCTGTTTTTCAAAGTGTTTATTTACTGCTGTTACTATTTGATTAGAATGTATTAAAT AAAAAAAACCTGATTTCTACAAGTTGCACTTATTGAGTTCTAGAGAACGTACACTTTCATGGTAATAGA GGATTGCCATAAAAACTTACGTCAAGTGAAATAAGCCAATTATTCAACAAAAGGTAGAACATTACTTGC CATTCTGTAAAGTTATGGGCTGTACCTGCCCCCTTTGCAATTTGGAAAGCATGGTTTAGAAACTACAGG CATTGTCAAGTGGCCGGGTCTTTTATAATTTGAATAGGCATAACACTGATGTCCTCTGTGTTTCCAAAA ACATGGTTTAGAAACTACAAACATTATGACATGGCCAGTCTTTTACAAGTTGAGTAGGCATAATACTAA AGAAAAATACAAAGTTTTGTGGCCACTTATTTTTTGCTATGTTAGTCTGCATAACTGTTATAAATGTAC CATCTTTTCTAGAGTCCAGACATTATTTATTTTATGGCTTTAAAATTTTCCTGCATAGCTACAATCCTG TGGTGTGTCACCATAAAGGTGGACCCTGTGTGAATGAGAAAATTCAGTTATAAATTGTAATAAAACCTG CTTACTGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003877.5
Synonyms	CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
Summary	This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Locus ID	8835
MW	62.5

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