BRSK2 (NM_003957) Human 3' UTR Clone

Specifications

Product Data
Product Name	BRSK2 (NM_003957) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C11orf7; PEN11B; SAD1; SADA; STK29
ACCN	NM_003957
Insert Size	1730 bp
Sequence Data	Insert Sequence (showhide) >SC212509 3’UTR clone of NM_003957 The sequence shown below is from the reference sequence of NM_003957. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCCAAATGTGGAATTATCCCGAAAAGTTAACATGTCACCTCCACGAGGCCATCCTCTGTGACCGAAGGC AGCTGCTGCGGACCCGCCCTCCCTCCGCTCCTGCTGTTGCTGCCGGGCAGTGAGGCCCAGCCCAGCGCC CCGTCCACCCCGCGGCAGCTCCTCGCCTCAGCTCCGCACGGCCCGTGGGAGGAAGGCCAGGCTCGGGGG AGCCTCCTCCAGCCCGGCCGACCCGGACTCCCGGTCACCTGACCCCTCAGCAAGAACAGCCTGCCTGGT GGCCTTCTGGGGCCAGGACCCCTGGTGGGCAACGTAGCCACAGGAACAGGCCCCGTCCACCGCCTCCAC GCCGCACCTGGAGGCCTCCTCGCAGGCCCGTGCCCCGCCTCCCTGGCTGCGCCGCCTCCGTGTAGTCTT GGCCTCCTCAGGCTGCCTCCCGTCCTCTCGTCTCACCCGCGCCTCCCTTGCCTCATCTGGGGCGGCTGT GGGCTCTGGCGCTCCTCTCTGGCTGAGGTGGAAACAGAGACACCCTGCGGCACCAGAGCCTTCCCAGCA GGCCAGGCCGCTGGGCTGGGATCAGTGTTATTTATTTGCCGTTTTAATTTATGGATTCTCCGCACCTCT GTTCAGGGAAGGGCGGCGGCCACATCCCCTGCCGTCTGCGTGTCTCAGGCAGTGGGGGGGCTGGGGCCA GGGCGCCCTCTGAGGACAGAGCTGGTGGGGCGCGGGGGGGCTGGCGAGCTACTGTAAACTTTAAAGAAT TCCTGCAAGATATTTTTATAAACTTTTTTTTCTTGGTGGTTTTTGGAAAAGGGTGTGGGGGTGGGGGCG CCGCTGGGGCAGGGCCAGGTTTTGTGTTTTAGTCCCTTGCTCCTGCTTCTTTCTACACACACATCTAAA GACGGTGCGGCTCGCTCTGTCATGGGTTCCGTCTCTCTGTGGAGAAGCAGCTCCACCTCTGGGGGGGCT CGGGGCAGAGGGGCGGTGTCTTGTAGCGGGCGGCAGCGCCAGCGCCCCTCTGTCAGGCTGGGGCAATCT TGGTTTTGTGTCCAAAGGTGAAGGGGTAGGAGGAGGGCCCTCAGCTGGCCCTCCCCACACACAGGACGG CAGGGGCACTGTGAGGCTTTTCTTATTAAAATGAAAAAATTGAAAAAAAAGGACAAAGAGTCGGTGGCG CTCCTCTGCAGGGCGTTCTGTGCAGAGCGAGGCCCAGGGCGCAGCCCTCAGAGGGCTGCAGGCCCACCC TGCCCAGTGCCCGCCGCCGTGCTTCACCCCAGCTCCAGCTTCTGTGTTCCCTTCCGCCCATGTGCCCAG CCCTCCCAGGCGGGCACAGCCCGGGTGCGGCGGCCGTGGGGGACGGCGGGTCTGATGCATGCCTCTGCC ATGGAGTCGTCTGTCTGCTTCGGTGCCTGCCCCTGCCTCCCACCCACCTCGTGTATAGATTTTAACGCT TCTGTTAACATTAGACCTCTGCCACAGGCTGGGATTTCTATACATAAGAACAAAAGCAAACACCTAGGA CAGCAAACGCCAGGCGGTACAGGCGGGAAGGGGCTCTCCACGGAGATCGAGGACACGAAGCAAACTGCC TCTTGCTTGCCTTCCCCTTTTGTGCTTCGGACACACGCGGACTCCAGCAGGCGCCACGGAAATGGGCAA GCCCCTGCAGTGTACCCCTGTCATAACTGTGAGCAGCTGCAGCTCCGGAACAATAAATCCCTTCCGCAA AGACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003957.4
Synonyms	C11orf7; PEN11B; SAD1; SADA; STK29
Summary	Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.[UniProtKB/Swiss-Prot Function]
Locus ID	9024
MW	60.3

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.