CIITA (NM_000246) Human 3' UTR Clone

Specifications

Product Data
Product Name	CIITA (NM_000246) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C2TA; CIITAIV; MHC2TA; NLRA
ACCN	NM_000246
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC212637 3’UTR clone of NM_000246 The sequence shown below is from the reference sequence of NM_000246. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAACAGGATTCACGGATCAGCCTGAGATGATCCCAGCTGTGCTCTGGACAGGCATGTTCTCTGAGGACA CTAACCACGCTGGACCTTGAACTGGGTACTTGTGGACACAGCTCTTCTCCAGGCTGTATCCCATGAGCC TCAGCATCCTGGCACCCGGCCCCTGCTGGTTCAGGGTTGGCCCCTGCCCGGCTGCGGAATGAACCACAT CTTGCTCTGCTGACAGACACAGGCCCGGCTCCAGGCTCCTTTAGCGCCCAGTTGGGTGGATGCCTGGTG GCAGCTGCGGTCCACCCAGGAGCCCCGAGGCCTTCTCTGAAGGACATTGCGGACAGCCACGGCCAGGCC AGAGGGAGTGACAGAGGCAGCCCCATTCTGCCTGCCCAGGCCCCTGCCACCCTGGGGAGAAAGTACTTC TTTTTTTTTATTTTTAGACAGAGTCTCACTGTTGCCCAGGCTGGCGTGCAGTGGTGCGATCTGGGTTCA CTGCAACCTCCGCCTCTTGGGTTCAAGCGATTCTTCTGCTTCAGCCTCCCGAGTAGCTGGGACTACAGG CACCCACCATCATGTCTGGCTAATTTTTCATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCT GGTCTCAAACTCTTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAAGCGTG AGCCACTGCACCGGGCCACAGAGAAAGTACTTCTCCACCCTGCTCTCCGACCAGACACCTTGACAGGGC ACACCGGGCACTCAGAAGACACTGATGGGCAACCCCCAGCCTGCTAATTCCCCAGATTGCAACAGGCTG GGCTTCAGTGGCAGCTGCTTTTGTCTATGGGACTCAATGCACTGACATTGTTGGCCAAAGCCAAAGCTA GGCCTGGCCAGATGCACCAGCCCTTAGCAGGGAAACAGCTAATGGGACACTAATGGGGCGGTGAGAGGG GAACAGACTGGAAGCACAGCTTCATTTCCTGTGTCTTTTTTCACTACATTATAAATGTCTCTTTAATGT CACAGGCAGGTCCAGGGTTTGAGTTCATACCCTGTTACCATTTTGGGGTACCCACTGCTCTGGTTATCT AATATGTAACAAGCCACCCCAAATCATAGTGGCTTAAAACAACACTCACATTTATTCTGCTCACATATC TGTCATTTGAGCAGGGCTCAGCGGGGACAGCTCCTTCTGTCCTACTCTGTGTCAGGTGGGGCAGCTTGA GGGTTGGGCTGGTGTCACCTGAAGACTCATTCTTCTGTACGTCTGACAGGCAATGCTGGCTGTTGGCTG GGGGCCTCAGTGCCACTACGGAATAGTTGGCTAGGACCCCTCCATGTGGGCTAGTTGGGCTTCCTCATA GTATGGTGGCTGGGTTGGAGGGTGTCCCAAAAAGAAAGGAGGGGATAGAGAGAGACCACTTTTCATAAC CTAGCCTTAGAAGTCACACAGTATTACTTCTGCTACATATATATGTTTTAAGAGGCAGGGTCTCACTCT GTCGCCCAGTCTGGAATGCAGTGGTATGATCACGGCTCACTGCAGCCTCAACCTCCTGGGCTAAGTGAT CCTCCCACCTCAGCCTCCCGAATAGCTGGGACTACAGGTGTGAGTCACCAAGCCCAGTTAATCTTTAGT TTTATTTTTGTAGAGCCAGGGTCTCACTATGTTGCCCAGGCAGGTCTTGAACTCCTGGCCTCAAGTGAT TCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAACCACCACACCCAGCCCACTTCTGCC ATATTCTGTTGGCCAGTGTGACAAGGATTGCTACTGTCCTACCCACCCTCCTTTCACCACATGTGCACA TGCACGTGTGTGCACGTACACACACATACACACACACGCGTGCACACACCAGAGCCCACCTTGGCTCAA GTCCTCTTTTCTGAGAGGACTTTTCTTTGTGGCTTCCTAAAATTCAGTGGAAAATTAATTGTTTGGGG AGCGGACCGACTTACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCC CAACCTGCCATCACGAGATTTCGATTCCACCGCCGC
Restriction Sites	SgfI-RsrII
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000246.4
Synonyms	C2TA; CIITAIV; MHC2TA; NLRA
Summary	This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Locus ID	4261
MW	71.9

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