VARP (ANKRD27) (NM_032139) Human 3' UTR Clone

Specifications

Product Data
Product Name	VARP (ANKRD27) (NM_032139) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	PP12899; VARP
ACCN	NM_032139
Insert Size	1169 bp
Sequence Data	Insert Sequence (showhide) >SC212794 3’UTR clone of NM_032139 The sequence shown below is from the reference sequence of NM_032139. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCCAAGAGGTTAGTGCTTCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGCAA GGATGCAACAAGATGATGCTGAGCGTGAACACATCTGAGAACTAAATGTGCTTCCATGAGACTGGCTTG AGAAGTCTTCAGCACCAAGTTCCTGAAAGCTTTTCTGTGGCAGGAAAGAATGCAACAAAAAAGTTAACC ACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATTGAAACAGACAAAAATTCCAGTAGCATCCA GATCCTTAAGCCAGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGGAGAGGTTT CACCACCGCATTCTGACCTCCTCCTCCCAAAAGGTGCTAAACCTCTCTGACCTGTGTACATTCACAAAC CACAGCTAGAATTCCTCCACCTAGGATTAAGCTGGAGAGAAGTAAGTAATTTAGGTTTCATGGTACTGT AGAGGCCAGGCTGAAATGTCATATCTGAAGGAAGAAAGCAGCAGCTGGACAATGTTTCTTTGCAAAGCA ACACTCGAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGGATGCATCAGACCTG TTCCACATCATGCACATGGGAAAGGGTGGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGT TACTACACGTGCACCTGTAGCAGTATTTCTAGAAACATCCCTTTTTGTTGAGAACCTCCCTTGAATGTC TGTCACACTCACACCTGACGGGATGGTTACTGGATTAGAGAGTAGATTTGGCACATCTTTTCTTAGTCT TTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTTTCGGTTAGAATTTATTGCCA TTTATTCCTTTTTATAAATTTCTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGT ATATGGGTTTGTCCTGAGTCCGTTTTCAAATGACCTTGTGATAGGGAAATGGTTTTGTCCATGTTCTTG GAAATACTTGTGTATGTACAGAAGGAAGGGAGGGATTATTTTTCTACAAAGTAATTTATGATTTCTAAT TTTCTAATGTGCCTTGGATATGTGCCAAATGATGGAAAAGAAACAGTAAACTTTATGATTCTTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_032139.3
Synonyms	PP12899; VARP
Summary	May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	84079
MW	45

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