LIM Kinase 1 (LIMK1) (NM_002314) Human 3' UTR Clone

Specifications

Product Data
Product Name	LIM Kinase 1 (LIMK1) (NM_002314) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	LIMK; LIMK-1
ACCN	NM_002314
Insert Size	1254 bp
Sequence Data	Insert Sequence (showhide) >SC213301 3’UTR clone of NM_002314 The sequence shown below is from the reference sequence of NM_002314. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTGCCTGCCCACCCTGAGGTCCCCGACTGAGCCAGGGCCACTCAGCTGCCCCTGTCCCCACCTCTGGAG AATCCACCCCCACCAGATTCCTCCGCGGGAGGTGGCCCTCAGCTGGGACAGTGGGGACCCAGGCTTCTC CTCAGAGCCAGGCCCTGACTTGCCTTCTCCCACCCCGTGGACCGCTTCCCCTGCCTTCTCTCTGCCGTG GCCCAGAGCCGGCCCAGCTGCACACACACACCATGCTCTCGCCCTGCTGTAACCTCTGTCTTGGCAGGG CTGTCCCCTCTTGCTTCTCCTTGCATGAGCTGGAGGGCCTGTGTGAGTTACGCCCCTTTCCACACGCCG CTGCCCCAGCAACCCTGTTCACGCTCCACCTGTCTGGTCCATAGCTCCCTGGAGGCTGGGCCAGGAGGC AGCCTCCGAACCATGCCCCATATAACGCTTGGGTGCGTGGGAGGGCGCACATCAGGGCAGAGGCCAAGT TCCAGGTGTCTGTGTTCCCAGGAACCAAATGGGGAGTCTGGGGCCCGTTTTCCCCCCAGGGGGTGTCTA GGTAGCAACAGGTATCGAGGACTCTCCAAACCCCCAAAGCAGAGAGAGGGCTGATCCCATGGGGCGGAG GTCCCCAGTGGCTGAGCAAACAGCCCCTTCTCTCGCTTTGGGTCTTTTTTTTGTTTCTTTCTTAAAGCC ACTTTAGTGAGAAGCAGGTACCAAGCCTCAGGGTGAAGGGGGTCCCTTGAGGGAGCGTGGAGCTGCGGT GCCCTGGCCGGCGATGGGGAGGAGCCGGCTCCGGCAGTGAGAGGATAGGCACAGTGGACCGGGCAGGTG TCCACCAGCAGCTCAGCCCCTGCAGTCATCTCAGAGCCCCTTCCCGGGCCTCTCCCCCAAGGCTCCCTG CCCCTCCTCATGCCCCTCTGTCCTCTGCGTTTTTTCTGTGTAATCTATTTTTTAAGAAGAGTTTGTATT ATTTTTTCATACGGCTGCAGCAGCAGCTGCCAGGGGCTTGGGATTTTATTTTTGTGGCGGGCGGGGGTG GGAGGGCCATTTTGTCACTTTGCCTCAGTTGAGCATCTAGGAAGTATTAAAACTGTGAAGCTTTCTCAG TGCACTTTGAACCTGGAAAACAATCCCAACAGGCCCGTGGGACCATGACTTAGGGAGGTGGGACCCACC CACCCCCATCCAGGAACCGTGACGTCCAAGGAACCAAACCCAGACGCAGAACAATAAAATAAATTCCGT ACTCCCCACCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002314.4
Synonyms	LIMK; LIMK-1
Summary	There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
Locus ID	3984
MW	44.4

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