MCM6 (NM_005915) Human 3' UTR Clone

Specifications

Product Data
Product Name	MCM6 (NM_005915) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	MCG40308; Mis5; P105MCM
ACCN	NM_005915
Insert Size	1239 bp
Sequence Data	Insert Sequence (showhide) >SC213336 3’UTR clone of NM_005915 The sequence shown below is from the reference sequence of NM_005915. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTTAACCCTAACTACTTGCTCGAAGATTGAGATAGTGAAAGTAACTGACCAGAGCTGAGGAACTGTGGC ACAGCACCTCGTGGCCTGGAGCCTGGCTGGAGCTCTGCTAGGGACAGAAGTGTTTCTGGAAGTGATGCT TCCAGGATTTGTTTTCAGAAACAAGAATTGAGTTGATGGTCCTATGTGTCACATTCATCACAGGTTTCA TACCAACACAGGCTTCAGCACTTCCTTTGGTGTGTTTCCTGTCCCAGTGAAGTTGGAACCAAATAATGT GTAGTCTCTATAACCAATACCTTTGTTTTCATGTGTAAGAAAAGGCCCATTACTTTTAAGGTATGTGCT GTCCTATTGAGCAAATAACTTTTTTTCAATTGCCAGCTACTGCTTTTATTCATCAAAATAAAATAACTT GTTCTGAAGTTGTCTATTGGATTTCTTTCTACTGTACCCTGATTATTACTTCCATCTACTTCTGAATGT GAGACTTTCCCTTTTTGCTTAACCTGGAGTGAAGAGGTAGAACTGTGGTATTATGGATGAGGTTTCTAT GAGAAGGAGTCATTAGAGAACTCATATGAAAGCTAGAGGCCTTAGAGATGACTTTCCAAGGTTAATTCC AGTTGTTTTTTTTTTTTTTTAAGTTTATAAAAGTTTATTATACTTTTTTAAAATTACTCTTTAGTAATT TATTTTACTTCTGTGTCCTAAGGGTAATTTCTCAGGATTGTTTTCAAATTGCTTTTTTAGGGGAAATAG GTCATTTGCTATATTACAAGCAATCCCCAAATTTTATGGTCTTCCAGGAAAAGTTATTACCGTTTATGA TACTAACAGTTCCTGAGACTTAGCTATGATCAGTATGTTCATGAGGTGGAGCAGTTCCTGTGTTGCAGC TTTTAACAACAGATGGCATTCATTAAATCACAAAGTATGTTAAAGGTCACAAAAGCAAAATAACTGTCT GAGGCTAAGGCCCACGTGGGACAGTCTAATACCCATGAGTACTCAACTTGCCTTGATGTCTGAGCTTTC CAGTGCAATGTGAATTTGAGCAGCCAGAAATCTATTAGTAGAAAGCAAGACAGATTAATATAGGTTAAA ACAATGATTTAAATATGTTTCTCCCAATAATTATCTCTTTCCCTGGAATCAACTTGTATGAAACCTTGT CAAAATGTACTCCACAAGTATGTACAATTAAGTATTTTAAAAATAAATGGCAAACATTAAAAACAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005915.6
Synonyms	MCG40308; Mis5; P105MCM
Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
Locus ID	4175
MW	47.7

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