COMT (NM_000754) Human 3' UTR Clone

Specifications

Product Data
Product Name	COMT (NM_000754) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HEL-S-98n
ACCN	NM_000754
Insert Size	1269 bp
Sequence Data	Insert Sequence (showhide) >SC213426 3’UTR clone of NM_000754 The sequence shown below is from the reference sequence of NM_000754. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGGGCCCAGGCAGCGAAGCAGGGCCCTGACTGCCCCCCCGGCCCCCCTCTCGGGCTCTCTCACCCAGC CTGGTACTGAAGGTGCCAGACGTGCTCCTGCTGACCTTCTGCGGCTCCGGGCTGTGTCCTAAATGCAAA GCACACCTCGGCCGAGGCCTGCGCCCTGACATGCTAACCTCTCTGAACTGCAACACTGGATTGTTCTTT TTTAAGACTCAATCATGACTTCTTTACTAACACTGGCTAGCTATATTATCTTATATACTAATATCATGT TTTAAAAATATAAAATAGAAATTAAGAATCTAAATATTTAGATATAACTCGACTTAGTACATCCTTCTC AACTGCCATTCCCCTGCTGCCCTTGACTTGGGCACCAAACATTCAAAGCTCCCCTTGACGGACGCTAAC GCTAAGGGCGGGGCCCCTAGCTGGCTGGGTTCTGGGTGGCACGCCTGGCCCACTGGCCTCCCAGCCACA GTGGTGCAGAGGTCAGCCCTCCTGCAGCTAGGCCAGGGGCACCTGTTAGCCCCATGGGGACGACTGCCG GCCTGGGAAACGAAGAGGAGTCAGCCAGCATTCACACCTTTCTGACCAAGCAGGCGCTGGGGACAGGTG GACCCCGCAGCAGCACCAGCCCCTCTGGGCCCCATGTGGCACAGAGTGGAAGCATCTCCTTCCCTACTC CCCACTGGGCCTTGCTTACAGAAGAGGCAATGGCTCAGACCAGCTCCCGCATCCCTGTAGTTGCCTCCC TGGCCCATGAGTGAGGATGCAGTGCTGGTTTCTGCCCACCTACACCTAGAGCTGTCCCCATCTCCTCCA AGGGGTCAGACTGCTAGCCACCTCAGAGGCTCCAAGGGCCCAGTTCCCAGGCCCAGGACAGGAATCAAC CCTGTGCTAGCTGAGTTCACCTGCACCGAGACCAGCCCCTAGCCAAGATTCTACTCCTGGGCTCAAGGC CTGGCTAGCCCCCAGCCAGCCCACTCCTATGGATAGACAGACCAGTGAGCCCAAGTGGACAAGTTTGGG GCCACCCAGGGACCAGAAACAGAGCCTCTGCAGGACACAGCAGATGGGCACCTGGGACCACCTCCACCC AGGGCCCTGCCCCAGACGCGCAGAGGCCCGACACAAGGGAGAAGCCAGCCACTTGTGCCAGACCTGAGT GGCAGAAAGCAAAAAGTTCCTTTGCTGCTTTAATTTTTAAATTTTCTTACAAAAATTTAGGTGTTTACC AATAGTCTTATTTTGGCTTATTTTTAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000754.4
Synonyms	HEL-S-98n
Summary	Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Locus ID	1312
MW	46

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