DUT (NM_001948) Human 3' UTR Clone

Specifications

Product Data
Product Name	DUT (NM_001948) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	dUTPase
ACCN	NM_001948
Insert Size	1325 bp
Sequence Data	Insert Sequence (showhide) >SC213761 3’UTR clone of NM_001948 The sequence shown below is from the reference sequence of NM_001948. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGAGGTTTTGGTTCCACTGGAAAGAATTAAAATTTATGCCAAGAACAGAAAACAAGAAGTCATACCTTT TTCTTAAAAAAAAAAAAAAAGTTTTTGCTTCAAGTGTTTTGGTGTTTTGCACTTCTGTAAACTTACTAG CTTTACCTTCTAAAAGTACTGCATTTTTTACTTTTTTTTATGATCAAGGAAAAGATCATTAAAAAAAAA CACAAAGAAGTTTTTCTTTGTGTTTGGATCAAAAAGAAACTTTGTTTTTCCGCAATTGAAGGTTGTATG TAAATCTGCTTTGTGGTGACCTGATGTAAACAGTGTCTTCTTAAAATCAAATGTAAATCAATTACAGAT TAAAAAAAAAAGCCTGTATTTAACTCATATGATCTCCCTTCAGCAACTTATTTTGCTTTAATTGCTTTA AATCTTAAGCAATATTTTTTATTCAGTAAACAAATTCTTTCACAAGGTACAAAATCTTGCATAAGCTGA ACTAAAATAAAAATGAAAAGGAGAGATTAAAGGTATTCCTTGTTCTTCCCTTCTCTTCACTAGTCTAAA AACTTCTTTTTAATCTTAAGATTCTTTGTGATGAGGGTGAGAAAAAGAATCCTCAGTTTATTTTTCCAC TATTAATCTTTCTTTTGATAAATCCTCTATTGACTGGGTAGAGGTATGTTTGTGAAAGACATGTAACTT GGGGATTTGTTACTTTAGGTTTGTTCCCTTGAATTTCATCTCATCAGGCAAATTGTACTAGTTGTAGTT ACGAGTTTTCCCTCAGTGAAGTAGCAATAGGCTGTAATCAAGAAAATATGCCATTTATAGAGATAAGAT AAATGAAATAATACTTCAGCCACCAGGTTTTTCTGTCTCACATACATAAGCAGCATTTCATTGCAGATA TGGGACTGATTCTGTGGCTTACCTTGATTAACATCTTTTGGAAGTTTTGCTAGTGTGCTTTCCTTTCTT TACTATGTTTCTCAGATTCCTTTGTATCAGGGTTTTGGGTGTCACTTAGGTTTTGTCCATCAGATTCTG TGAGACACCAGGCATCGTTTTGAGGATGTGGGTTATACACATGGAGTGCTTCTGGAACTATCAGCCCAC TTGACCACCCAGTTTGTGGAAGCACAGGCAAGAGTGTTCTTTTCTGGTGATTCTCCAGGCCATTTAATA CCCTGCAATGTAATTGTCCCTCTGTGGCTCACATTTCATTAGTGAGCCATGAAATCAACTCAGTGGGAC ATAGCCAGCATTTTTGCATACCAGGTTGGGCTATAAAATATTTCTGTTGTCAATAAATTTTAAATGTTT TCCTGCTAAACTAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001948.4
Synonyms	dUTPase
Summary	This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Locus ID	1854
MW	51.3

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