YTHDF1 (NM_017798) Human 3' UTR Clone

Specifications

Product Data
Product Name	YTHDF1 (NM_017798) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C20orf21
ACCN	NM_017798
Insert Size	1309 bp
Sequence Data	Insert Sequence (showhide) >SC213819 3’UTR clone of NM_017798 The sequence shown below is from the reference sequence of NM_017798. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGGAACGGCAGAGTCGAAACAAACAATGAGGGCGAACCAGTTTCTTACATGTTCTAACGTTTGACTTT GAAAACAGTTTAAAACACGTGTGCTTGGTCAGCTCCAGTGTGTCGTCCCGTGCGGGGGTTGAGTGTTGC ATCTTTGCCTTTCTTGTCGTTGATTTTTGCCCAGATGGATCTGCATTTATTTGTACTTTTTCTATGTAT TATAATCCTGTAGAAGTCACTAATAAAGGAGTATTTTTTTTGTCAGCTTATCAATCAGACTGATCTAAT GTGAAATGTAAGTATCCTTAAAAACAAAGCATCTATTTTGGCAGAAATTGTGTTCTTAAATTCAGTCAT TTGATATTCTGTGAGACTTCATATTTCTCATCCCTTTATTGCTTTTTAGCAAACATAAGAAACCATGAG TCATTTTGTCATTTAGAGTATTCTGATAAAATCTCTTGAAAATACTGAAATCAAAAGGTTAATGATTTT TTGTTCATTCTGATTTGTCATTTTATTATCTGTTATCGGTCTAAAGTGCTAATTTACCCATTTGATTTT TCTGCTAGACAGATAACTTTTAATTTTTCAAATTTGGCAGACACTTTTTTTTTTTTTTTGAAAATCTTT CCTTCCAGATCTGTTGCCCACTGAACAGCCACCCGTCCCTCACTGTCCTGGTGTCCGATTGGGCTGGAT GGTGTTGGGGCATGATGTGTGGAGGAACTGGAAGGTGCTTTAGGTCTGGTTCAGGGTCGGGCATTCTTT GTTGTTTGCACATCTTTTTAAATTTTACACCTTTTCTTAAGAATTCTAATGCCGTCTTAAGTTTTTATA CCAATAATGCTGAGCTTTAAGTGTAGGATCTGGTAGTACAGACAGTGTGATGGATGATGCTGCTGGTTG TAAATTTCATCGTGTGTGTCTAATTTTTTTTCCTGTTGAATGGGTAAAAACAAAACAAAACTTTTTTTA GAAGATGAATTTGCTGTCATGTTTTGTGGAATGAGGGACCGTTGAGCTCACTACCACCTGGAGTTTGAG TTGAAGCATGAAAATGGTGCCCATGCCTGACGCTCCAGCGCCTGGATCTGCACGTGCCCTTGTAGAGGA TCCTTACCGTCCTAGAGAGCAGACGCTTTCTGAAAACTACTTGCTCCAAAAGACCCTCTGAGTTAACGT TTCAGCTGTATCATTAGACTTGTATTTAGAGCGTGTCACTTCCTCTGAACTGTTACTGCCTGAATGGAG TCCTGGACGACATTGGGTTTTTCCTCTAGGAGAATACAAGCCTTAATAAACAATACTATTTAGCAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017798.4
Synonyms	C20orf21
Summary	Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). Required to facilitate learning and memory formation in the hippocampus by enhancing protein synthesis upon neuronal stimulation: in response to neuronal stimulation, binds to m6A-containing neuronal mRNAs, promoting their translation, thereby contributing to learning and memory (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts, thereby promoting their translation (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). Acts by binding and promoting translation of m6A-containing transcripts encoding proteins involved in lysosomal degradation and phagosome maturation, leading to increased antigen degradation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	54915
MW	50.1

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.