KCTD11 (NM_001002914) Human 3' UTR Clone

Specifications

Product Data
Product Name	KCTD11 (NM_001002914) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C17orf36; KCASH1; REN; REN/KCTD11
ACCN	NM_001002914
Insert Size	1333 bp
Sequence Data	Insert Sequence (showhide) >SC213970 3’UTR clone of NM_001002914 The sequence shown below is from the reference sequence of NM_001002914. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCCAGGTCTCTGCGCTTTGTCCGGCACTGAGGATGCTGTTCTCAGTTTGACTGTGGGGAGGAGAGAGAA TGGGGTACTAGCACCCCTGAAGCCTCTTTCCAGCTCTGCTTCAGGAGCTATGAGAGTCGGGACTCTCCT GCACCTGACTGGAGCTCAGATGTGGGCAGGAATTCCCAAACCTGAGCCCACCAAGGACTCACAAGTGGT CCAGAAGGTCTCAACCTGTGCTGACCCTGGGAGGGGTAGGGAAGGTTCTCTCAGCTTGTTCTTGCCTAA GGCTGAGCACCTCCAGTCTCTCCTTGATTTGGAGCTCAGTGTTTAAGGGCTTGGAAAAGGGGGGAACAT CTCTTTACCCAGACTAGACCTAGCAAAACCCTGGAAGGATATTGAGGTCTGGGGAAAAGGGAGGACTTT GCATTTTCCCAATGCGGTCTCTTGGACCATGGCTTCTACTCCTGAAGCTGGGTGGCCTGGCCTGGCCTG ACCAATGAGAGGCCAGAACACTCTGGAACATCGGAAGAGGAGTTCTTTGCTATGTTCCAAGCCATCTAC TGAGGGAGGCAGAAAGGCCACAACCCACCCTAGGTTGATGTATGGGAGCTAGGACAGTCCCCATGGCAA TGGGGCTGGAGCATCCCTCATCTGGAAGAATCCCATACTGATGGCAGGGCTGGCCAGGGGGAAGAGGGT AGTATCTGTGGGTCCTGGCCTTTCTTCATGTGTGCGTGCATATCAGCCCGTGTGGCTGACTGATGTATA GGTCCCTGGCATCCTGGTTCATATCTGTGTTGCTGACTACAGTGTCTGTGATGTCCGCATGTCCAGGCC TGTTTGGGGTTGCCTAGCGACTCTTCTGGCACAGGGTGTGTCTGTGGTATACCTGTGAGGTGGTTGACA ATTAGTAGTTTAATCACAGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTATGTGCACGCATGTATATG CATCACCACGTAGCCAGGAGGGGCCTGTTGGGGTTTGAGTCACTGGGATCTTCCTGGTGAGAGGTAAGA GAAGTCACTGGGCTTAGCTGGGCCTCTGAGGCCTGTATGGAACTCTTGGTTGCTGAGGCAACCATGGAC CTGTTGCTAGGAGATAGCTGGGGAAGGCCCAAGGCCGCCCAGGGCAGAGAGAGGAGACGAAGAGTTTGG GACAGTGGGGGAGGAGATGGGAAGGGATGGGATTTCTGGGTCCCAGAGCGGGTGGGATACTCACGCACA GCTTCTTCACTGGTGGGGGGTGGGGCACACATTATTTCTCACTGGTCATGATTTACAAGAAGAAAAATA AAACTGCTTTTGGAACCACAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001002914.3
Synonyms	C17orf36; KCASH1; REN; REN/KCTD11
Summary	Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.[UniProtKB/Swiss-Prot Function]
Locus ID	147040
MW	49.2

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