Endostatin (COL18A1) (NM_030582) Human 3' UTR Clone

Specifications

Product Data
Product Name	Endostatin (COL18A1) (NM_030582) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GLCC; KNO; KNO1; KS
ACCN	NM_030582
Insert Size	1352 bp
Sequence Data	Insert Sequence (showhide) >SC214023 3’UTR clone of NM_030582 The sequence shown below is from the reference sequence of NM_030582. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGAACAGCTTCATGACTGCCTCCAAGTAGCCACCGCCTGGATGCGGATGGCCGGAGAGGACCGGCGGC TCGGAGGAAGCCCCCACCGTGGGCAGGGAGCGGCCGGCCAGCCCCTGGCCCCAGGACCTGGCTGCCATA CTTTCCTGTATAGTTCACGTTTCATGTAATCCTCAAGAAATAAAAGGAAGCCAAAGAGTGTATTTTTTT AAAAGTTTAAAACAGAAGCCTGATGCTGACATTCACCTGCCCCAACTCTCCCCTGACCTGTGAGCCCAG CTGGGTCAGGCAGGGTGCAGTATCATGCCCTGTGCAACCTCTTGGCCTGATCAGACCACGGCTCGATTT CTCCAGGATTTCCTGCTTTGGGAAGCCGTGCTCGCCCCAGCAGGTGCTGACTTCATCTCCCACCTAGCA GCACCGTTCTGTGCACAAAACCCAGACCTGTTAGCAGACAGGCCCCGTGAGGCAATGGGAGCTGAGGCC ACACTCAGCACAAGGCCATCTGGGCTCCTCCAGGGTGTGTGCTCGCCCTGCGGTAGATGGGAGGGAGGC TCAGGTCCCTGGGGCTAGGGGGAGCCCCTTCTGCTCAGCTCTGGGCCATTCTCCACAGCAACCCCAGGC TGAAGCAGGTTCCCAAGCTCAGAGGCGCACTGTGACCCCCAGCTCCGGCCTGTCCTCCAACACCAAGCA CAGCAGCCTGGGGCTGGCCTCCCAAATGAGCCATGAGATGATACATCCAAAGCAGACAGCTCCACCCTG GCCGAGTCCAAGCTGGGAGATTCAAGGGACCCATGAGTTGGGGTCTGGCAGCCTCCCATCCAGGGCCCC CATCTCATGCCCCTGGCTGGGACGTGGCTCAGCCAGCACTTGTCCAGCTGAGCGCCAGGATGGAACACG GCCACATCAAAGAGGCTGAGGCTGGCACAGGACATGCGGTAGCCAGCACACAGGGCAGTGAGGGAGGGC TGTCATCTGTGCACTGCCCATGGACAGGCTGGCTCCAGATGCAGGGCAGTCATTGGCTGTCTCCTAGGA AACCCATATCCTTACCCTCCTTGGGACTGAAGGGGAACCCCGGGGTGCCCACAGGCCGCCCTGCGGGTG AACAAAGCAGCCACGAGGTGCAACAAGGTCCTCTGTCAGTCACAGCCACCCCTGAGATCCGGCAACATC AACCCGAGTCATTCGTTCTGTGGAGGGACAAGTGGACTCAGGGCAGCGCCAGGCTGACCACAGCACAGC CAACACGCACCTGCCTCAGGACTGCGACGAAACCGGTGGGGCTGGTTCTGTAATTGTGTGTGATGTGAA GCCAATTCAGACAGGCAAATAAAAGTGACCTTTTACACTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_030582.4
Synonyms	GLCC; KNO; KNO1; KS
Summary	This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Locus ID	80781
MW	48.3

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