THRAP3 (NM_005119) Human 3' UTR Clone

Specifications

Product Data
Product Name	THRAP3 (NM_005119) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BCLAF2; TRAP150
ACCN	NM_005119
Insert Size	1370 bp
Sequence Data	Insert Sequence (showhide) >SC214122 3’UTR clone of NM_005119 The sequence shown below is from the reference sequence of NM_005119. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGGACAATATACAGCCCACAACCGAGTAGGGGCCACCCTTGACGGGATTCCTGCCCAGGGGAGAGAGG CGCTGGGAAGATGGCTGGTGAGGAGCTTAACAGAGGAACCTCAAGAAGATTCTGAAAATCCTACCCCCA CCCCCCACCAGCCGCACAGATTGTACTACCGCGAGAGGCATCCCTGGCGCTGTCTCCCACTGGACAGAG GAGGCTGGCCATGGGGCCCAGGGGTCAGGCCCAGCTTTTGAGCAGAATACAACGCATTGGGCTTTAGCT GTTTTTCTCATTTGTTGGTGTGTGGGGTGGGGGCAGGGGTAGGGCGGGAGAGCGATGCTTGGATTTTTG TTTCCTATTAGAAACCAACAGTTTTGTTCTAATTTCATTTCATTTGGAGCTAAGATGACTAATTTGATG ATTTTCGATCTCTTTTCCCCTGTCCTGATTTTAAAAGCCCCCTCCTTTTTTTTTTTTTTTTTCTTTTTT TAGGCATATGTAGTAATATTAGAAACATTTAATTTGGGAAACTTTGATTCTTGAAAGAGAAAACAAAAG CATGTGAATAAACTTTGAAGTGTTCACCTCAGTTTGGGACCAAACTGCTTGGATCTTTGTAAAAACCGG TTTTGTATGTCAAGGAGGAGTTTAAGGCCTTTCCGACCACCTTGTGTTCCCCTTTTCTGCGCAGCCATG TATCACGTGGAGTTGCTCCTTACCACACCTCACGTGCCCCTGAGCCCTATTTCCTGATTTCTTCTGGGC TGGACTTCCCCGTTCTCCACCAGCAGCTCCAGTATCCCAAACTTTCTAGTCCTGCTGATCCTCCCAGCA ACGGGGTGGAAACTGGAGGGCAGTGTCTGGTCTGTTTTCTAAGAAACTTATGAATTCTATTATCTTTAC AAATATGAGAAAATTTTTTCAATATTTTTTATTAATCTTTTTATAAAATGAAAAGAAACTCCTATGATC GATTAAGGAAGGTGGTTATGGCTGGGTGGTTCAGGGGTTTTTTTGGGTTTCTTTTTTTTTTTCTTTGTC TTTTTAACCTTAAGCTGTTTAAGTTGAAGCATTCTCAGATGTTTGGGGGGAAACATCCTCTTAAAATGG GTCCTTGTGCTTGCCTTCTGGGGAGGCGGTCCTGAGCAGGTGAATCATAAGGCATTTATGCATATGTTA TATGCGGACTGCACCCACCTCTCCCCCCCAGCCTTTGCCTCTTGCGTTGTTGTGCTGCTTTCCCCTTAC TTTGCTACATTTCTATAGTTAAGTTGGTTTTACTTGAATGATTCATGTTTAGGGGGAAAATGAAAATCT CCCTTAAAATTTGTTTCAACTCCTCCTGCAAATAAAATAAATGAAGTGGCAGATGTAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005119.4
Synonyms	BCLAF2; TRAP150
Summary	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).[UniProtKB/Swiss-Prot Function]
Locus ID	9967
MW	51.5

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