ALS2 (NM_001135745) Human 3' UTR Clone

Specifications

Product Data
Product Name	ALS2 (NM_001135745) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ALS2CR6; ALSJ; IAHSP; PLSJ
ACCN	NM_001135745
Insert Size	1381 bp
Sequence Data	Insert Sequence (showhide) >SC214146 3’UTR clone of NM_001135745 The sequence shown below is from the reference sequence of NM_001135745. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATGGGCTTTTCTTTAGAAACTTTAAAATGAGTAAGGCTTGGTAGCATTTTTTATTTTTTGAGTTTGATT ATAATTTTGTTTTATCAGGCAAGCCTAGATAAAGGAAAGAACCTGGATTAATTCAAAATCACTCTTTAT GTTTGTTCTGGCCCTTTATGATATTGAAAGGTGTCATGTTGGGCTTGTTTTATAAGTAGGAGCATTTCA TTTTTTTTTCTTGCTAGTACTTTTTTTCTATGGCTAAAGTACTGAATTTTGGTGGGCCCTGAATAGTTT AATATAACTAGAGATTCACAAAGATTCTTCTTACTTGTGTTTGTAACACTCTTCAGAATTCTGTAGAGA AAAGTCTTTTCCTTCTTTAACAGGGAAGATTGTTTTGTGGCAGATCCTTCAATTGTAGGCAGATTTAAA ACTTACAGGCAATTACATGTTTCAGTTTTTTTCAATTATAGCTGTGGTCCTTACTGGGCTTAATTTGAA GAGGTGGCTAATATTTTATCTTTTTGTTTGTTTGTTTTTGAGATGGGGTCTTGCTCTGTCACCCAGGCT GGAGTGCAGTAATGCGATTGTGGCTCACTGCAGCCTCGATCTCCCAGGTTCAAGCGATCCTCCCATTTC AGCCTTCCAAGTAGCTGGGACTATACACATGCCACCACACCTGCTGATTTTATTTTTAAGTAGAGTAGA GCCTGTTGCCCAGGCTCATCTCAAACTCCTGAGCTCAAGCAATCCTCCCACCTCAGCCTCCCAAAGTGT TGAGATTACAGGCATGAGCCATCATGCCCAGCCTATTTTATATATCTTATTAAAACTATTTTCATTTTG AAGATTTGTGGTAGAATGAACAAAAGTTGTTTATCAGTAGCACATGGTAAAGTTTGAGTTCCCGCTTAA ACTAAATTGTTTTAAAAGGATTATTTCTGTGTTTTACTCTTAGTGTGGCCTTTTGATTTTGCTTTACCA AAACTGTAAGAAAACAAAACAAAAGATCATACTCATAAAAGATCTGTCCTGCAGTGTTTCTTTTTAGGT TTTTGAAACCACATAGCCTCTTGATTCTCAATTCTTATTGTTTACTCTGTCAGAATGTGAACATGAAGG TATTTTTAGAAATAGTCTTTATTTCACAATCTATTCACTGAAACTTGTGGGTATTTGAATTTTTAAAAA AATCAAGGATAAGCTGTTTGGAGAAAGGTATTATAAAGTCTGAACAAAGCAAAAGTAGTAGTTTAACAA GAATGCATGTAGAAAATTCTTAGACTGTACATGCTTATCACATTTTACTTACTTTGTTAAACATTGGAA GTTTTTGTTACTTATGCTAGTAACAATGTGTGTGTTTCTATTGAATTAAATTTAATTTATTTAAATTAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001135745.2
Synonyms	ALS2CR6; ALSJ; IAHSP; PLSJ
Summary	The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Locus ID	57679
MW	53.3

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