TAF4 (NM_003185) Human 3' UTR Clone

Specifications

Product Data
Product Name	TAF4 (NM_003185) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	TAF(II)130; TAF(II)135; TAF2C; TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135
ACCN	NM_003185
Insert Size	1400 bp
Sequence Data	Insert Sequence (showhide) >SC214319 3’UTR clone of NM_003185 The sequence shown below is from the reference sequence of NM_003185. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTGCTGCTCTACAAAGCATTCCTTAAGTGACACAGGAGGACGCCTGGGGACTTTTTATATATTTGCAGA TTACGCCTTTTTGTAACGAGCAAATGGGATATTGTTTAAAAAACAGCCACCTCTTTACAATGGAACAGT TTTATATTCCTGTTTCTAAATCAGCTCTTCAGTGTGAAAGAAAACACGTTTCTGTAACAGAGAGAACAC AAAGGCCTGTGGATACTCTTAAAGGACAATTAAATCTTAACTCATCTTGATTGAGTGGCCTTCCTGCCA AACAAGCCATATATAAAGACTGATGGAATCGTTAGCAAATAATTAGCTGCCCTCTGTCAACTCATAGCA GTTTCTGCATTATTTGTGCATTTTGGTTTAGTTCTACCTAACTTACTATGTAGGTGTATGTCTACAGCC GATGACCTCATTTCGTTTATTTTATTTTTGTAATAGTCAGTTGGCAAAGCAAACTGATTTTTTAGACTA TTTATCTTCCTTCCCTTCCCCTCCCACCCCGCTCTCCTCTCTGCCCCCTGCCCTCCCCTCCCCTCCCTT CCCCTCCACTCCGCTGAGAATCCTGGAGGAATACACAATTCATCGTTGCACCCCCACCTCAGAGTGTAA TCGCATTTCTGCTTGGTAGAGGCCGAGCCCAGCAAAGGTGGCTCCTTCTGAATGTGTGGTCAGCATCTG TACAAATGCATTTTATTTGCTATAGTTTGTAAAGCTGTAAAGTTAAAAGAGATGAAAACCTTTTCAGCA TAAATATATTTTACTTGCACTGTGTTTTTTAGCTAAAAGTGAAAACCTAGATTAAATAAAATCAAAGTT GAGAAGAATCATCAAAAGACTGTTTCTCGGTGTGAATCAAGTGTTGAAAAATGGTTGGTGTATTTTGTC AGTAATTGTACATAACTTTTGGCACATGACATAGAAATGGCTATGTAAACTATAATTATTTTGCTAAGA GACTGTATGCAAGCCTTGGGCCGACTTTACAGACGTCCAGAGCAAAGCCCCTTCTTTGTACCTATTTTT TTATTACAAATATACTAATTGGTTCTTTCTATTTTCAGAGGTTATTGTATGAAATTGTCTATTGATAGT ACTTTTATGACTGTAAATACTCTGGCTTTCTCCGTGTGAATTCTCACATTAGACTTTAATTCGAGCGCG TGTGAACTGAACGCTGATCAGTATTTTTTATCAACACCTGAGAACTGTTACACCTTTTATTTTGTCTTT TAGGAAATCCCTGTCTTTCCATTTTTTCATGTAAATTTTGCACAGTTACTTGTTCATATGTAAATATTT TACTTTCAGAAATGAAGTTTTTAATTGCTATTGTTTTATATAGGATTGAAAGAAAATTAACTCCTTTAT TAAAAACAAATTTATCTGTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003185.4
Synonyms	TAF(II)130; TAF(II)135; TAF2C; TAF2C1; TAF4A; TAFII-130; TAFII-135; TAFII130; TAFII135
Summary	Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
Locus ID	6874
MW	53.9

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